ArticleJournal of neurodevelopmental disorders2012
Toward epigenetic and gene regulation models of specific language impairment: looking for links among growth, genes, and impairments.
Article in Journal of neurodevelopmental disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Characterizing the Growth in Utterance Length, Grammaticality, and Subordination in Spanish and English in Bilingual Children.Language, speech, and hearing services in schools · 2026Article
- Neuro-cognitive development of semantic and syntactic bootstrapping in 7- to 9-year-old children.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Insights From Language-Trained Apes: Brain Network Plasticity and Communication.Evolutionary anthropology · 2025Review
- Spanish Bilingual Morphosyntactic Development in Bilingual Children With and Without Developmental Language Disorder: Articles, Clitics, Verbs, and the Subjunctive Mood.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Longitudinal Grammaticality Judgments of Tense Marking in Complex Questions in Children With and Without Specific Language Impairment, Ages 5-18 Years.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Longitudinal Examination of Morphosyntactic Skills in Bilingual Children: Spanish and English Standardized Scores.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Adversity Exposure, Syntax, and Specific Language Impairment: An Exploratory Study.Journal of speech, language, and hearing research : JSLHR · 2022Article
- The Genetic and Molecular Basis of Developmental Language Disorder: A Review.Children (Basel, Switzerland) · 2022Review
- Work Setting Effects on Speech-Language Pathology Practice: Implications for Identification of Children With Specific Language Impairment.American journal of speech-language pathology · 2022Article
- Family-Based Whole-Exome Analysis of Specific Language Impairment (SLI) Identifies Rare Variants inBrain sciences · 2021Article
- Study of rare genetic variants inMeta gene · 2021Article
- Autism Spectrum Disorder and Childhood Apraxia of Speech: Early Language-Related Hallmarks across Structural MRI Study.Journal of personalized medicine · 2020Article
- Causal Pathways for Specific Language Impairment: Lessons From Studies of Twins.Journal of speech, language, and hearing research : JSLHR · 2020Review
- Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal Cognition.Journal of speech, language, and hearing research : JSLHR · 2020Article
- Syntactic and Semantic Specialization and Integration in 5- to 6-Year-Old Children during Auditory Sentence Processing.Journal of cognitive neuroscience · 2020Article
- The Finite Verb Morphology Composite: Values From a Community Sample.Journal of speech, language, and hearing research : JSLHR · 2019Article
- 'Developmental Delay' Reconsidered: The Critical Role of Age-Dependent, Co-variant Development.Frontiers in psychology · 2018Article
- Language growth in children with heterogeneous language disorders: a population study.Journal of child psychology and psychiatry, and allied disciplines · 2017Article
- How Stuttering Develops: The Multifactorial Dynamic Pathways Theory.Journal of speech, language, and hearing research : JSLHR · 2017Review
- Grammar Is Differentially Impaired in Subgroups of Autism Spectrum Disorders: Evidence from an Investigation of Tense Marking and Morphosyntax.Frontiers in psychology · 2017Article
Corrections and comments
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1 author.
Funding
Abstract
Children with specific language impairment (SLI) are thought to have an inherited form of language impairment that spares other developmental domains. SLI shows strong heritability and recent linkage and association studies have replicated results for candidate genes. Regulatory regions of the genes may be involved. Behavioral growth models of language development of children with SLI reveal that the onset of language is delayed, and the growth trajectories of children with SLI parallel those of younger children without SLI. The rate of language acquisition decelerates in the pre-adolescent period, resulting in immature language levels for the children with SLI that persist into adolescence and beyond. Recent genetic and epigenetic discoveries and models relevant to language impairment are reviewed. T cell regulation of onset, acceleration, and deceleration signaling are described as potential conceptual parallels to the growth timing elements of language acquisition and impairment. A growth signaling disruption (GSD) hypothesis is proposed for SLI, which posits that faulty timing mechanisms at the cellular level, intrinsic to neurocortical functioning essential for language onset and growth regulation, are at the core of the growth outcomes of SLI. The GSD highlights the need to document and account for growth patterns over childhood and suggests needed directions for future investigation.
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Registered trials
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