ArticleBMC microbiology2012
Diversity of pili-specific bacteriophages: genome sequence of IncM plasmid-dependent RNA phage M.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
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- Structure and Mechanism of the Lipid Flippase MurJ.Annual review of biochemistry · 2022Review
- Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages.Microorganisms · 2021Article
- Rapid de novo evolution of lysis genes in single-stranded RNA phages.Nature communications · 2020Article
- ssRNA phage penetration triggers detachment of the F-pilus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Single-gene lysis in the metagenomic era.Current opinion in microbiology · 2020Review
- Experimental support for multidrug resistance transfer potential in the preterm infant gut microbiota.Pediatric research · 2020Observational
- Expansion of known ssRNA phage genomes: From tens to over a thousand.Science advances · 2020Article
- Metatranscriptomic reconstruction reveals RNA viruses with the potential to shape carbon cycling in soil.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data.Journal of nanobiotechnology · 2019Article
- Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.The Journal of biological chemistry · 2019Review
- CRISPR analysis suggests that small circular single-stranded DNA smacoviruses infect Archaea instead of humans.Nature communications · 2019Article
- Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer.Virus research · 2018Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteriophages of the Leviviridae family are small RNA viruses with linear, positive-sense, single-stranded RNA genomes that encode only four proteins. All phages of this family require bacterial pili to attach to and infect cells. Leviviridae phages utilizing F-pili for this purpose have been extensively studied. RNA phages specific for conjugative plasmid-encoded pili other than that of plasmid F have been isolated, but are much less understood and their relation to the F-pili-specific phages in many cases is not known.
resultsPhage M has the smallest known Leviviridae genome to date and has the typical genome organization with maturation, coat and replicase genes in the 5' to 3' direction. The lysis gene is located in a different position than in other known Leviviridae phages and completely overlaps with the replicase gene in a different reading frame. It encodes a 37 residue long polypeptide that contains a transmembrane helix like the other known lysis proteins of leviviruses. Sequence identities of M proteins to those of other phages do not exceed 25% for maturation protein, 51% for coat protein and 41% for replicase. Similarities in protein sequences and RNA secondary structures at the 3' untranslated region place phage M together with phages specific for IncP, IncC and IncH, but not IncF plasmid-encoded pili. Phylogenetic analysis using the complete genome sequences and replicase proteins suggests that phage M represents a lineage that branched off early in the course of RNA phage specialization on different conjugative plasmids.
conclusionsThe genome sequence of phage M shows that it is clearly related to other conjugative pili-specific leviviruses but has an atypical location of the lysis gene. It provides a better view on the remarkable diversification of the plasmid-specific RNA phages.
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