ArticleThe FEBS journal2013
Discontinuous thoracic venous cardiomyocytes and heart exhibit synchronized developmental switch of troponin isoforms.
Article in The FEBS journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Characteristics of Sarcomere Proteins in Myocardial Sleeves of the Superior Vena Cava and Pulmonary Veins of the Porcine Heart.Bulletin of experimental biology and medicine · 2025Article
- Automatic Activity Arising in Cardiac Muscle Sleeves of the Pulmonary Vein.Biomolecules · 2021Review
- The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci.The journal of physiological sciences : JPS · 2019Article
- The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy.The Journal of physiology · 2019Article
- Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation.Stem cells (Dayton, Ohio) · 2019Article
- Electrophysiological characteristics of the rat azygos vein under electrical pacing and adrenergic stimulation.The journal of physiological sciences : JPS · 2018Article
- HIC2 regulates isoform switching during maturation of the cardiovascular system.Journal of molecular and cellular cardiology · 2018Article
- Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?American journal of respiratory cell and molecular biology · 2017Review
- Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation.G3 (Bethesda, Md.) · 2017Article
- Morpho-functional characterization of the systemic venous pole of the reptile heart.Scientific reports · 2017Article
- CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice.American journal of respiratory cell and molecular biology · 2016Article
- The Correlation between Serum Level of Leptin and Troponin in Children with Major Beta-Thalassemia.Iranian journal of pediatric hematology and oncology · 2015Article
- Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.Nature communications · 2014Article
- Physiological contractility of cardiomyocytes in the wall of mouse and rat azygos vein.American journal of physiology. Cell physiology · 2014Article
- Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells.PloS one · 2014Article
- Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review.Frontiers in physiology · 2014Review
- The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia.International cardiovascular research journal · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiomyocyte-like cells have been reported in thoracic veins of rodents and other mammals, but their differentiation state and relationship to the muscle mass in the heart remain to be characterized. Here we investigated the distribution, ultrastructure, expression and developmental regulation of myofilament proteins of mouse and rat pulmonary and azygos venous cardiomyocytes. Tracing cardiomyocytes in transgenic mouse tissues using a lacZ reporter gene driven by a cloned rat cardiac troponin T promoter demonstrated scattered distribution of cardiomyocytes discontinuous from the atrial sleeves. The longitudinal axis of venous cardiomyocytes is perpendicular to that of the vessel. These cells contain typical sarcomere structures and intercalated discs as shown in electron microscopic images, and express cardiac isoforms of troponin T, troponin I and myosin. The expression of troponin I isoform genes and the alternative splicing of cardiac troponin T in thoracic venous cardiomyocytes are regulated during postnatal development in precise synchrony with that in the heart. However, the patterns of cardiac troponin T splicing in adult rat thoracic venous cardiomyocytes are slightly but clearly distinct from those in the atrial and ventricular muscles. The data indicate that mouse and rat thoracic venous cardiomyocytes residing in extra-cardiac tissue possess a physiologically differentiated state and an intrinsically pre-set developmental clock, which are apparently independent of the very different hemodynamic environments and functional features of the vessels and heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.