ArticleJournal of the American Geriatrics Society2012
Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Factors associated with handgrip strength across the life course: A systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Effect of Angiotensin-Converting Enzyme Inhibitors on Physical Function in Elderly Subjects: A Systematic Review and Meta-Analysis.Drugs & aging · 2015Pooled it
- Statins, mood, sleep, and physical function: a systematic review.European journal of clinical pharmacology · 2014Pooled it
- Amelioration of gait and balance disorders by rosuvastatin is associated with changes in cerebrovascular reactivity in older patients with hypertensive treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Effect of Antihypertensive and Statin Medication Use on Muscle Performance in Community-Dwelling Older Adults Performing Strength Training.Drugs & aging · 2021Trial
- Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Effects of 96 Weeks of Rosuvastatin on Bone, Muscle, and Fat in HIV-Infected Adults on Effective Antiretroviral Therapy.AIDS research and human retroviruses · 2016Trial
- Effects of randomized rosuvastatin compared with placebo on bone and body composition among HIV-infected adults.AIDS (London, England) · 2015Trial
- Statin use does not impair muscle health in older adults: findings from the SCOPE study.Aging clinical and experimental research · 2026Article
- The association between statins and gait speed reserve in older adults: effects of concomitant medication.GeroScience · 2026Observational
- Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.Journal of cachexia, sarcopenia and muscle · 2025Article
- Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians.Molecular and cellular biochemistry · 2025Review
- Associations Between Hypertension, Angiotensin-Converting Enzyme Inhibitors, and Physical Performance in Very Old Adults: Results from the ilSIRENTE Study.The Journal of frailty & aging · 2024Article
- Associations between hypertension and cognitive, mood, and behavioral parameters in very old adults: results from the IlSIRENTE study.Frontiers in public health · 2023Article
- Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults.The Journal of frailty & aging · 2023Article
- Low handgrip strength is associated with diabetic foot disease in geriatric patients with type 2 diabetes.Turkish journal of medical sciences · 2022Article
- Rewinding sarcopenia: a narrative review on the renin-angiotensin system.Aging clinical and experimental research · 2021Review
- Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study.Scientific reports · 2021Article
- Critical Illness and the Frailty Syndrome: Mechanisms and Potential Therapeutic Targets.Anesthesia and analgesia · 2020Review
- Association between Statin Use and Physical Function among Older Chinese Inpatients with Type 2 Diabetes.The journal of nutrition, health & aging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesTo examine associations between angiotensin-converting enzyme (ACE) inhibitor and statin medications and baseline and mean annual change in physical performance measures and muscle strength in older women.
designProspective cohort study.
participantsParticipants from the Women's Health Initiative Clinical Trials aged 65 to 79 at baseline who had physical performance measures, self-report of health insurance, and no prior history of stroke or congestive heart failure were included (N = 5,777). Women were recruited between 1993 and 1998. MEASUREMENTS: Medication use was ascertained through a baseline inventory. Physical performance measures (timed 6-m walk, repeated chair stands in 15 seconds) and grip strength were assessed at baseline and follow-up Years 1, 3, and 6. Multivariable-adjusted linear repeated-measures models were adjusted for demographic and health characteristics.
resultsACE inhibitor use was associated with lower mean grip strength at baseline (22.40 kg, 95% confidence interval (CI) = 21.89-22.91 vs 23.18 kg, 95% CI 23.02-23.34; P = .005) and greater mean annual change in number of chair stands (-0.182, 95% CI -0.217 to -0.147 vs -0.145, 95% CI -0.156 to -0.133; P = .05) than nonuse. Statin use was not significantly associated with baseline measures or mean annual change for any outcome. A subgroup analysis suggested that statin use was associated with less mean annual change in chair stands (P = .006) in the oldest women.
conclusionThese results do not support an association between statin or ACE inhibitor use and slower decline in physical performance or muscle strength and thus do not support the use of these medications for preserving functional status in older adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.