ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
KAYAK-α modulates circadian transcriptional feedback loops in Drosophila pacemaker neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 25 citations in OpenAlex.
- TARANIS Interacts with VRILLE and PDP1 to Modulate the Circadian Transcriptional Feedback Mechanism inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Integrated omics in Drosophila uncover a circadian kinome.Nature communications · 2020Article
- Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment.PLoS genetics · 2019Article
- Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors.BMC neuroscience · 2018Article
- Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep.PLoS genetics · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis.PLoS genetics · 2016Article
- Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii.BMC genomics · 2015Article
- Studying circadian rhythms in Drosophila melanogaster.Methods (San Diego, Calif.) · 2014Review
- Circadian period integrates network information through activation of the BMP signaling pathway.PLoS biology · 2013Article
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Authors and funding
3 authors at 1 institution in 2 countries.
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Abstract
Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops in animals. In Drosophila, the dimeric transcription factor CLOCK/CYCLE (CLK/CYC) promotes period (per), timeless (tim), vrille (vri), and PAR-domain protein 1 (Pdp1) transcription. PER and TIM negatively feed back on CLK/CYC transcriptional activity, whereas VRI and PDP1 negatively and positively regulate Clk transcription, respectively. Here, we show that the α isoform of the Drosophila FOS homolog KAYAK (KAY) is required for normal circadian behavior. KAY-α downregulation in circadian pacemaker neurons increases period length by 1.5 h. This behavioral phenotype is correlated with decreased expression of several circadian proteins. The strongest effects are on CLK and the neuropeptide PIGMENT DISPERSING FACTOR, which are both under VRI and PDP1 control. Consistently, KAY-α can bind to VRI and inhibit its interaction with the Clk promoter. Interestingly, KAY-α can also repress CLK activity. Hence, in flies with low KAY-α levels, CLK derepression would partially compensate for increased VRI repression, thus attenuating the consequences of KAY-α downregulation on CLK targets. We propose that the double role of KAY-α in the two transcriptional loops controlling Drosophila circadian behavior brings precision and stability to their oscillations.
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