ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 99 citations in OpenAlex.
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- Article
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- The effects of diazepam on sleep depend on the photoperiod.Acta pharmacologica Sinica · 2025Article
- Neural circuits and emotional processing in rapid eye movement sleep.Frontiers in psychiatry · 2025Review
- Circadian activity and sleep architecture in autism spectrum disorder mouse model withFrontiers in sleep · 2025Article
- A hypothalamus-lateral periaqueductal gray GABAergic neural projection facilitates arousal following sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2024Article
- Coincident development and synchronization of sleep-dependent delta in the cortex and medulla.Current biology : CB · 2024Article
- DELTA-RHYTHMIC ACTIVITY IN THE MEDULLA DEVELOPS COINCIDENT WITH CORTICAL DELTA IN SLEEPING INFANT RATS.bioRxiv : the preprint server for biology · 2024Article
- Article
- Prefrontal Cortical Regulation of REM Sleep.Research square · 2023Article
- Prefrontal cortical regulation of REM sleep.Nature neuroscience · 2023Article
- A Narrative Review on REM Sleep Deprivation: A Promising Non-Pharmaceutical Alternative for Treating Endogenous Depression.Journal of personalized medicine · 2023Review
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.Journal of Huntington's disease · 2023Review
- GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.Nature communications · 2022Article
- Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla.Current biology : CB · 2022Article
- Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice.Neuroscience bulletin · 2021Article
- Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings.Current neurology and neuroscience reports · 2020Review
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Authors and funding
7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
It has recently been shown that the ventrolateral part of the periaqueductal gray (VLPAG) and the adjacent dorsal deep mesencephalic nucleus (dDpMe) contain GABAergic neurons gating paradoxical sleep (PS) onset by means of their projection to the glutamatergic PS-on neurons of the sublaterodorsal tegmental nucleus (SLD). To determine the mechanisms responsible for the cessation of activity of these GABAergic PS-off neurons at the onset and during PS, we combined the immunostaining of c-FOS, a marker of neuronal activation, with cholera toxin b subunit (CTb) retrograde tracing from the VLPAG/dDpMe in three groups of rats (control, PS deprived, and PS hypersomniac). We found that the lateral hypothalamic area (LH) is the only brain structure containing a very large number of neurons activated during PS hypersomnia and projecting to the VLPAG/dDpMe. We further demonstrated that 44% of these neurons express the neuropeptide melanin concentrating hormone (MCH). We then showed that bilateral injections in the LH of two inhibitory compounds, clonidine (an α-2 adrenergic agonist) and muscimol (a GABAa agonist) induce an inhibition of PS. Furthermore, after muscimol injections in the LH, the VLPAG/dDpMe contained a large number of activated neurons, mostly GABAergic, and projecting to the SLD. Altogether, our results indicate for the first time that the activation of a population of LH neurons, in part MCH containing, is necessary for PS to occur. Furthermore, our results strongly suggest that these neurons trigger PS by means of their inhibitory projection to the PS-off GABAergic neurons located in the VLPAG/dDpMe.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.