ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 116 citations in OpenAlex.
- Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial.Psychopharmacology · 2019Trial
- Dopamine, time perception, and future time perspective.Psychopharmacology · 2018Trial
- Dopamine Depletion Reduces Food-Related Reward Activity Independent of BMI.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine.American journal of therapeuticsTrial
- Dopamine modulation of motor and implicit learning contributions to auditory temporal attention.iScience · 2026Article
- The Role of Spontaneous Eye Blinks in Temporal Perception: An Eye Tracking Study.Journal of eye movement research · 2025Article
- VNTR Polymorphisms in theBioengineering (Basel, Switzerland) · 2025Article
- Balancing excitation and inhibition: The role of neural network dynamics in working memory gating.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset.Scientific reports · 2023Article
- Article
- Pupillometry tracks errors in interval timing.Behavioral neuroscience · 2022Article
- A proxy measure of striatal dopamine predicts individual differences in temporal precision.Psychonomic bulletin & review · 2022Article
- Dopaminergic Modulation of Dynamic Emotion Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effects of Methylphenidate on the Dopamine Transporter and Beyond.Current topics in behavioral neurosciences · 2022Article
- How movements shape the perception of time.Trends in cognitive sciences · 2021Review
- Dopamine and the interdependency of time perception and reward.Neuroscience and biobehavioral reviews · 2021Review
- An fMRI Study Using a Combined Task of Interval Discrimination and Oddball Could Reveal Common Brain Circuits of Cognitive Change.Frontiers in psychiatry · 2021Article
- Uncoupling Sensation and Perception in Human Time Processing.Journal of cognitive neuroscience · 2020Article
- Neural Basis of Increased Cognitive Control of Impulsivity During the Mid-Luteal Phase Relative to the Late Follicular Phase of the Menstrual Cycle.Frontiers in human neuroscience · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropsychological investigations of patients with Parkinson's disease, schizophrenia, or attention deficit disorder converge with psychopharmacological studies in animals and healthy volunteers to implicate dopamine (DA) pathways in timing. In parallel, single-cell recording and functional neuroimaging studies have highlighted the importance of basal ganglia, prefrontal cortex, and supplementary motor area (SMA) for timing. In a placebo-controlled, within-subject design, we combined event-related functional magnetic resonance imaging with a DA manipulation (acute phenylalanine/tyrosine depletion; APTD) in healthy volunteers to pinpoint the neuroanatomical and functional substrates of the DA modulation of timing. Behaviorally, APTD selectively impaired accuracy of perceptual timing, with no effect on performance of a color-control task matched for difficulty, working memory (WM), and attentional demands. Neurally, APTD attenuated timing-specific activity in the putamen and SMA. Notably, APTD-induced decreases in brain activity were directly correlated to APTD-induced impairments in timing performance. Moreover, APTD modulated timing-specific activity selectively during initial storage of the sample duration, but had no effect during its subsequent retrieval or comparison to a probe. Our results do not simply reflect DA modulation of WM since the color task controlled for the WM updating process necessary for timing of durations in the seconds range. Moreover, preliminary evidence indicated APTD effects on putamen and SMA were greater for subsecond (540 ms) than suprasecond (1080 ms) durations, when WM demands would actually be lower. Instead, we show for the first time in healthy humans that DA manipulation perturbs timing by attenuating the activity in putamen and SMA that mediates initial storage of temporal information into WM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.