ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Hippocampal phase precession from dual input components.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Direct entorhinal control of CA1 temporal coding.Nature communications · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- The generation of a neuronal phase code for space.Clinical and translational medicine · 2024Article
- A model of working memory for encoding multiple items and ordered sequences exploiting the theta-gamma code.Cognitive neurodynamics · 2023Article
- Homogeneous inhibition is optimal for the phase precession of place cells in the CA1 field.Journal of computational neuroscience · 2022Article
- Synaptic learning rules for sequence learning.eLife · 2021Article
- Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network.eLife · 2019Article
- Hippocampal Sequences During Exploration: Mechanisms and Functions.Frontiers in cellular neuroscience · 2019Review
- Article
- Neural mechanisms of navigation involving interactions of cortical and subcortical structures.Journal of neurophysiology · 2018Review
- Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling.Neuron · 2017Article
- Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells.Nature neuroscience · 2017Article
- Article
- Silencing CA3 disrupts temporal coding in the CA1 ensemble.Nature neuroscience · 2016Article
- PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.Scientific reports · 2016Article
- The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity.Nature neuroscience · 2015Article
- Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping.eLife · 2015Article
- State-dependencies of learning across brain scales.Frontiers in computational neuroscience · 2015Review
- Modeling inheritance of phase precession in the hippocampal formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Reversed theta sequences of hippocampal cell assemblies during backward travel.Nature neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phase precession is a well known phenomenon in which a hippocampal place cell will fire action potentials at successively earlier phases (relative to the theta-band oscillations recorded in the local field potential) as an animal moves through the cell's receptive field (also known as a place field). We present a model in which CA1 pyramidal cell spiking is driven by dual input components arising from CA3 and EC3. The receptive fields of these two input components overlap but are offset in space from each other such that as the animal moves through the model place field, action potentials are driven first by the CA3 input component and then the EC3 input component. As CA3 synaptic input is known to arrive in CA1 at a later theta phase than EC3 input (Mizuseki et al., 2009; Montgomery et al., 2009), CA1 spiking advances in phase as the model transitions from CA3-driven spiking to EC3-driven spiking. Here spike phase is a function of animal location, placing our results in agreement with many experimental observations characterizing CA1 phase precession (O'Keefe and Recce, 1993; Huxter et al., 2003; Geisler et al., 2007). We predict that experimental manipulations that dramatically enhance or disrupt activity in either of these areas should have a significant effect on phase precession observed in CA1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.