ArticleProceedings of the National Academy of Sciences of the United States of America2012
Specific and reversible DNA-directed self-assembly of oil-in-water emulsion droplets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Real-Time Fluorescence-Based Method for Dynamic Quantification of Droplet Network Assembly.ACS omega · 2025Article
- Internal State of Vesicles Affects Higher Order State of Vesicle Assembly and Interaction.ACS omega · 2024Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- Oil-on-water droplets faceted and stabilized by vortex halos in the subphase.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dynamic Light Scattering Based Microrheology of End-Functionalised Triblock Copolymer Solutions.Polymers · 2023Article
- DNA-Modified Liquid Crystal Droplets.Biosensors · 2022Article
- Photo-printing of faceted DNA patchy particles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Toward long-lasting artificial cells that better mimic natural living cells.Emerging topics in life sciences · 2019Article
- Autonomous dynamic control of DNA nanostructure self-assembly.Nature chemistry · 2019Article
- Sequential self-assembly of DNA functionalized droplets.Nature communications · 2017Article
- Rich complex behaviour of self-assembled nanoparticles far from equilibrium.Nature communications · 2017Article
- Kinetic control of the coverage of oil droplets by DNA-functionalized colloids.Science advances · 2016Article
- Crowding-induced cooperativity in DNA surface hybridization.Scientific reports · 2015Article
- Volume and porosity thermal regulation in lipid mesophases by coupling mobile ligands to soft membranes.Nature communications · 2015Article
- Droplets: unconventional protocell model with life-like dynamics and room to grow.Life (Basel, Switzerland) · 2014Review
- Evolution of oil droplets in a chemorobotic platform.Nature communications · 2014Article
- On-demand droplet fusion: a strategy for stimulus-responsive biosensing in solution.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Programming chemistry in DNA-addressable bioreactors.Journal of the Royal Society, Interface · 2014Article
- Enhanced nucleic acid amplification with blood in situ by wire-guided droplet manipulation (WDM).Biosensors & bioelectronics · 2014Article
- The MATCHIT automaton: exploiting compartmentalization for the synthesis of branched polymers.Computational and mathematical methods in medicine · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher-order structures that originate from the specific and reversible DNA-directed self-assembly of microscopic building blocks hold great promise for future technologies. Here, we functionalized biotinylated soft colloid oil-in-water emulsion droplets with biotinylated single-stranded DNA oligonucleotides using streptavidin as an intermediary linker. We show the components of this modular linking system to be stable and to induce sequence-specific aggregation of binary mixtures of emulsion droplets. Three length scales were thereby involved: nanoscale DNA base pairing linking microscopic building blocks resulted in macroscopic aggregates visible to the naked eye. The aggregation process was reversible by changing the temperature and electrolyte concentration and by the addition of competing oligonucleotides. The system was reset and reused by subsequent refunctionalization of the emulsion droplets. DNA-directed self-assembly of oil-in-water emulsion droplets, therefore, offers a solid basis for programmable and recyclable soft materials that undergo structural rearrangements on demand and that range in application from information technology to medicine.
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