SynthesisNeurology2013
Depression in epilepsy: a systematic review and meta-analysis.
Synthesis in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Cited by 146 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy
Who cites it
146 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Prevalence of Depression Among Patients with Epilepsy in Saudi Arabia: A Nationwide Systematic Review and Meta-Analysis.Neurosciences (Riyadh, Saudi Arabia) · 2026Pooled it
- Prevalence and associated factors of depression among adult patients with epilepsy in Ethiopia: a systematic review and meta-analysis, 2025.BMC psychiatry · 2025Pooled it
- Associations between epileptic seizures in pregnancy and adverse pregnancy outcomes: A systematic review and meta-analysis.PLoS medicine · 2025Pooled it
- Service delivery, behavioural, and self-management interventions for adults with epilepsy.The Cochrane database of systematic reviews · 2025Pooled it
- Effectiveness of Shugan Jieyu capsules for psychiatric symptoms of epilepsy: a systematic review and meta-analysis.BMC complementary medicine and therapies · 2024Pooled it
- Prevalence and factors associated with depressive symptoms among patients with epilepsy in Ethiopia: a national-based systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics.Computational intelligence and neuroscience · 2022Pooled it
- Depression among epileptic patients and its association with drug therapy in sub-Saharan Africa: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Mindfulness-based interventions in epilepsy: a systematic review.BMC neurology · 2017Pooled it
- Antidepressants for people with epilepsy and depression.The Cochrane database of systematic reviews · 2014Pooled it
- Telephone-based depression self-management in Hispanic adults with epilepsy: a pilot randomized controlled trial.Translational behavioral medicine · 2021Trial
- Depressive Symptom Severity in Individuals With Epilepsy and Recent Health Complications.The Journal of nervous and mental disease · 2019Trial
- Protocol for the ENCODE trial: evaluating a novel online depression intervention for persons with epilepsy.BMC psychiatry · 2017Trial
- Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy.Neurology · 2015Trial
- Association of depression and epilepsy in rural northern Rwanda: a prospective longitudinal study with a patient-centered approach.Epilepsy & behavior reports · 2026Article
- The Menopause Transition and Epilepsy: A Focus on Therapeutics.Neurology. Clinical practice · 2026Review
- Association Between a Body Shape Index and Epilepsy Among US Adults: Potential Indirect Pathway Through Depressive Symptoms.Brain and behavior · 2026Article
- Observational
- Comparative efficacy of agomelatine and escitalopram in people with epilepsy and comorbid major depressive disorder: A double-blind randomized controlled trial.Epilepsy & behavior reports · 2026Article
- Effect Modification of Alcohol Use on Epilepsy: NHIS Longitudinal Study.Biomedicines · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the prevalence of depression in persons with epilepsy (PWE) and the strength of association between these 2 conditions.
methodsThe MEDLINE (1948-2012), EMBASE (1980-2012), and PsycINFO (1806-2012) databases, reference lists of retrieved articles, and conference abstracts were searched. Content experts were also consulted. Two independent reviewers screened abstracts and extracted data. For inclusion, studies were population-based, original research, and reported on epilepsy and depression. Estimates of depression prevalence among PWE and of the association between epilepsy and depression (estimated with reported odds ratios [ORs]) are provided.
resultsOf 7,106 abstracts screened, 23 articles reported on 14 unique data sources. Nine studies reported on 29,891 PWE who had an overall prevalence of active (current or past-year) depression of 23.1% (95% confidence interval [CI] 20.6%-28.31%). Five of the 14 studies reported on 1,217,024 participants with an overall OR of active depression of 2.77 (95% CI 2.09-3.67) in PWE. For lifetime depression, 4 studies reported on 5,454 PWE, with an overall prevalence of 13.0% (95% CI 5.1-33.1), and 3 studies reported on 4,195 participants with an overall OR of 2.20 (95% CI 1.07-4.51) for PWE.
conclusionsEpilepsy was significantly associated with depression and depression was observed to be highly prevalent in PWE. These findings highlight the importance of proper identification and management of depression in PWE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.