Trial reportNeurology2013
Stroke Prognostication using Age and NIH Stroke Scale: SPAN-100.
Trial report in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Early Predictive Accuracy of Machine Learning for Hemorrhagic Transformation in Acute Ischemic Stroke: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Traditional and machine learning models for predicting haemorrhagic transformation in ischaemic stroke: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Machine learning and deep learning algorithms in stroke medicine: a systematic review of hemorrhagic transformation prediction models.Journal of neurology · 2024Pooled it
- Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation.Stroke · 2022Pooled it
- Radiological predictors of hemorrhagic transformation after acute ischemic stroke: An evidence-based analysis.The neuroradiology journal · 2020Pooled it
- Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous recombinant tissue plasminogen activator: a systematic review and meta-analysis.Stroke and vascular neurology · 2018Pooled it
- Postacute Care Setting, Facility Characteristics, and Poststroke Outcomes: A Systematic Review.Archives of physical medicine and rehabilitation · 2018Pooled it
- Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: External Validation of Prediction Models.Stroke · 2023Trial
- TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis.Neurocritical care · 2016Trial
- The THRIVE score strongly predicts outcomes in patients treated with the Solitaire device in the SWIFT and STAR trials.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Impact of age and baseline NIHSS scores on clinical outcomes in the mechanical thrombectomy using solitaire FR in acute ischemic stroke study.AJNR. American journal of neuroradiology · 2014Trial
- THRIVE score predicts outcomes with a third-generation endovascular stroke treatment device in the TREVO-2 trial.Stroke · 2013Trial
- Associated Factors of Hemorrhagic Transformation in Patients Undergoing Anterior Circulation Thrombectomy: Data from a Comprehensive Stroke Center in Vietnam.Journal of clinical medicine · 2026Article
- Baseline Neurological Severity and Early Imaging Findings Predict 3-Month Functional Outcome in Anterior-Circulation Acute Ischemic Stroke: A Retrospective Cohort Study with One-Year Follow-Up.Journal of clinical medicine · 2026Article
- Advanced Multimodal AI for Predicting Long-Term Functional Outcomes After Ischemic Stroke Using Only Admission Data.Research square · 2026Article
- Real-world experience of the large 6 × 50 mm Aperio Stent-retriever: evaluation of effectiveness and safety.Neuroradiology · 2026Article
- ANGWC Nomogram for Predicting Poor 3-month Outcome after Intravenous Thrombolysis in Young and Middle-Aged Patients with First-Ever Stroke.Thrombosis and haemostasis · 2026Article
- Role of high-density area score in predicting outcomes of large-vessel occlusion stroke after endovascular treatment.European radiology · 2026Article
- Development and validation of the ANGS score for predicting long-term outcomes in acute ischemic stroke patients receiving intravenous thrombolysis.BMC medical informatics and decision making · 2026Article
- Clinical outcome following best medical management in acute stroke with a proximal isolated occlusion of the anterior cerebral artery: an international multicentre study.European stroke journal · 2026Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAge and stroke severity are major determinants of stroke outcomes, but systematically incorporating these prognosticators in the routine practice of acute ischemic stroke can be challenging. We evaluated the effect of an index combining age and stroke severity on response to IV tissue plasminogen activator (tPA) among patients in the National Institute of Neurological Disorders and Stroke (NINDS) tPA stroke trials.
methodsWe created the Stroke Prognostication using Age and NIH Stroke Scale (SPAN) index by combining age in years plus NIH Stroke Scale (NIHSS) ≥100. We applied the SPAN-100 index to patients in the NINDS tPA stroke trials (parts I and II) to evaluate its ability to predict clinical response and risk of intracerebral hemorrhage (ICH) after thrombolysis. The main outcome measures included ICH (any type) and a composite favorable outcome (defined as a modified Rankin Scale score of 0 or 1, NIHSS ≤1, Barthel index ≥95, and Glasgow Outcome Scale score of 1) at 3 months. Bivariate and multivariable logistic regression analyses were used to determine the association between SPAN-100 and outcomes of interest.
resultsAmong 624 patients in the NINDS trials, 62 (9.9%) participants were SPAN-100 positive. Among those receiving tPA, ICH rates were higher for SPAN-100-positive patients (42% vs 12% in SPAN-100-negative patients; p < 0.001); similarly, ICH rates were higher in SPAN-100-positive patients (19% vs 5%; p = 0.005) among those not receiving tPA. SPAN-100 was associated with worse outcomes. The benefit of tPA, defined as favorable composite outcome at 3 months, was present in SPAN-100-negative patients (55.4% vs 40.2%; p < 0.001), but not in SPAN-100-positive patients (5.6% tPA vs 3.9%; p = 0.76). Similar trends were found for secondary outcomes (e.g., symptomatic ICH, catastrophic outcome, discharge home).
conclusionThe SPAN-100 index could be a simple method for estimating the clinical response and risk of hemorrhagic complications after tPA for acute ischemic stroke. These results need further confirmation in larger contemporary datasets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.