ArticleJournal of bacteriology2013
Impact of Lactobacillus plantarum sortase on target protein sorting, gastrointestinal persistence, and host immune response modulation.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Functional Characterization of a Putative Sortase FA1364 inInternational journal of molecular sciences · 2026Article
- A Peek into the Relationship Between Probiotic Characteristics of Lactiplantibacillus plantarum Strains and Sortase A Gene Expression.Current microbiology · 2025Article
- Surface display of two neoantigens on Lactiplantibacillus plantarum.Scientific reports · 2025Article
- Probiogenomic analysis ofHeliyon · 2025Article
- Development of aApplied and environmental microbiology · 2024Article
- The Role of Proteomics in Identification of Key Proteins of Bacterial Cells with Focus on Probiotic Bacteria.International journal of molecular sciences · 2024Review
- Anthocyanins-rich cranberry extract attenuates DSS-induced IBD in an intestinal flora independent manner.Current research in food science · 2024Article
- Whole Genome Sequencing of the Novel Probiotic StrainMicroorganisms · 2023Article
- Determining the potential use of biosurfactants in preventing endodontic infections.European journal of oral sciences · 2022Article
- Probiotic Properties and Optimization of Gamma-Aminobutyric Acid Production byJournal of microbiology and biotechnology · 2022Article
- The Edible Plant Microbiome represents a diverse genetic reservoir with functional potential in the human host.Scientific reports · 2021Article
- Evaluation of probiotic characteristics and whole genome analysis of Pediococcus pentosaceus MR001 for use as probiotic bacteria in shrimp aquaculture.Scientific reports · 2021Article
- Selection and characterization of a SpaCBA pilus-secreting food-grade derivative of Lacticaseibacillus rhamnosus GG.Applied microbiology and biotechnology · 2021Article
- Article
- Role of Sortase A inFrontiers in microbiology · 2019Article
- Assembly of Synthetic Functional Cellulosomal Structures onto the Cell Surface of Lactobacillus plantarum, a Potent Member of the Gut Microbiome.Applied and environmental microbiology · 2018Article
- Genomic assessment in Lactobacillus plantarum links the butyrogenic pathway with glutamine metabolism.Scientific reports · 2017Article
- Article
- Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome.Microbial biotechnology · 2016Review
- Gene expression of Lactobacillus plantarum and the commensal microbiota in the ileum of healthy and early SIV-infected rhesus macaques.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sortases are transpeptidases that couple surface proteins to the peptidoglycan of Gram-positive bacteria, and several sortase-dependent proteins (SDPs) have been demonstrated to be crucial for the interactions of pathogenic and nonpathogenic bacteria with their hosts. Here, we studied the role of sortase A (SrtA) in Lactobacillus plantarum WCFS1, a model Lactobacillus for probiotic organisms. An isogenic srtA deletion derivative was constructed which did not show residual SrtA activity. DNA microarray-based transcriptome analysis revealed that the srtA deletion had only minor impact on the full-genome transcriptome of L. plantarum, while the expression of SDP-encoding genes remained completely unaffected. Mass spectrometry analysis of the bacterial cell surface proteome, which was assessed by trypsinization of intact bacterial cells and by LiCl protein extraction, revealed that SrtA is required for the appropriate subcellular location of specific SDPs and for their covalent coupling to the cell envelope, respectively. We further found that SrtA deficiency did not affect the persistence and/or survival of L. plantarum in the gastrointestinal tract of mice. In addition, an in vitro immature dendritic cell (iDC) assay revealed that the removal of surface proteins by LiCl strongly affected the proinflammatory signaling properties of the SrtA-deficient strain but not of the wild type, which suggests a role of SDPs in host immune response modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.