ArticleDevelopment (Cambridge, England)2013
A transiently expressed connexin is essential for anterior neural plate development in Ciona intestinalis.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordate Ciona.Current biology : CB · 2023Article
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordatebioRxiv : the preprint server for biology · 2023Article
- Fold Change Detection in Visual Processing.Frontiers in neural circuits · 2021Article
- Cellular identity and CaScientific reports · 2020Article
- Trpc1 as the Missing Link Between the Bmp and CaScientific reports · 2019Article
- Parallel visual circuitry in a basal chordate.eLife · 2019Article
- T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.Cell reports · 2015Article
- Quantitative and in toto imaging in ascidians: working toward an image-centric systems biology of chordate morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Review
- Exploiting the extraordinary genetic polymorphism of ciona for developmental genetics with whole genome sequencing.Genetics · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A forward genetic screen in the ascidian Ciona intestinalis identified a mutant line (frimousse) with a profound disruption in neural plate development. In embryos with the frimousse mutation, the anteriormost neural plate cells, which are products of an FGF induction at the blastula and gastrula stages, initially express neural plate-specific genes but fail to maintain the induced state and ultimately default to epidermis. The genetic lesion in the frimousse mutant lies within a connexin gene (cx-11) that is transiently expressed in the developing neural plate in a temporal window corresponding to the period of a-lineage neural induction. Using a genetically encoded calcium indicator we observed multiple calcium transients throughout the developing neural plate in wild-type embryos, but not in mutant embryos. A series of treatments at the gastrula and neurula stages that block the calcium transients, including gap junction inhibition and calcium depletion, were also found to disrupt the development of the anterior neural plate in a similar way to the frimousse mutation. The requirement for cx-11 for anterior neural fate points to a crucial role for intercellular communication via gap junctions, probably through mediation of Ca(2+) transients, in Ciona intestinalis neural induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.