ArticleAnnual reviews in control2012
Challenges and Recent Progress in the Development of a Closed-loop Artificial Pancreas.
Article in Annual reviews in control, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses.Journal of diabetes science and technology · 2018Trial
- Real-Time Detection of Infusion Site Failures in a Closed-Loop Artificial Pancreas.Journal of diabetes science and technology · 2018Trial
- Duration of Infusion Set Survival in Lipohypertrophy Versus Nonlipohypertrophied Tissue in Patients with Type 1 Diabetes.Diabetes technology & therapeutics · 2016Trial
- Evaluation of Intradermal and Subcutaneous Infusion Set Performance Under 24-Hour Basal and Bolus Conditions.Journal of diabetes science and technology · 2015Trial
- Preliminary evaluation of a new semi-closed-loop insulin therapy system over the prandial period in adult patients with type 1 diabetes: the WP6.0 Diabeloop study.Journal of diabetes science and technology · 2014Trial
- Susceptibility of interstitial continuous glucose monitor performance to sleeping position.Journal of diabetes science and technology · 2013Trial
- Artificial Pancreas and Closed-Loop Insulin Delivery: From Early Concepts to AI-Driven Diabetes Automation.Biosensors · 2026Review
- PID-controller enhanced artificial β-cells.PloS one · 2026Article
- Review
- Incorporating Uncertainty Estimation and Interpretability in Personalized Glucose Prediction Using the Temporal Fusion Transformer.Sensors (Basel, Switzerland) · 2025Article
- An AI-based module for interstitial glucose forecasting enabling a "Do-It-Yourself" application for people with type 1 diabetes.Frontiers in digital health · 2025Article
- Shortcomings in the Evaluation of Blood Glucose Forecasting.IEEE transactions on bio-medical engineering · 2024Article
- An injectable and biodegradable zwitterionic gel for extending the longevity and performance of insulin infusion catheters.Nature biomedical engineering · 2024Article
- How can we reach the target of glucose control in type 1 diabetes?Journal of diabetes · 2023Article
- Continuous glucose monitoring for automatic real-time assessment of eating events and nutrition: a scoping review.Frontiers in nutrition · 2023Article
- A new generation of sensors for non-invasive blood glucose monitoring.American journal of translational research · 2023Review
- Two Decades of Research in Artificial Pancreas: Insights from a Bibliometric Analysis.Journal of diabetes science and technology · 2022Article
- A New Meal Absorption Model for Artificial Pancreas Systems.Journal of diabetes science and technology · 2022Article
- GLYFE: review and benchmark of personalized glucose predictive models in type 1 diabetes.Medical & biological engineering & computing · 2022Review
- Impact of Accelerating Insulin on an Artificial Pancreas System Without Meal Announcement: An In Silico Examination.Journal of diabetes science and technology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Pursuit of a closed-loop artificial pancreas that automatically controls the blood glucose of individuals with type 1 diabetes has intensified during the past six years. Here we discuss the recent progress and challenges in the major steps towards a closed-loop system. Continuous insulin infusion pumps have been widely available for over two decades, but "smart pump" technology has made the devices easier to use and more powerful. Continuous glucose monitoring (CGM) technology has improved and the devices are more widely available. A number of approaches are currently under study for fully closed-loop systems; most manipulate only insulin, while others manipulate insulin and glucagon. Algorithms include on-off (for prevention of overnight hypoglycemia), proportional-integral-derivative (PID), model predictive control (MPC) and fuzzy logic based learning control. Meals cause a major "disturbance" to blood glucose, and we discuss techniques that our group has developed to predict when a meal is likely to be consumed and its effect. We further examine both physiology and device-related challenges, including insulin infusion set failure and sensor signal attenuation. Finally, we discuss the next steps required to make a closed-loop artificial pancreas a commercial reality.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.