Evidence map›Paper›PMID 23175606›Full record

ArticleNucleic acids research2013

WholeCellKB: model organism databases for comprehensive whole-cell models.

Jonathan R Karr, Jayodita C Sanghvi, Derek N Macklin, Abhishek Arora, Markus W Covert

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Multi-scale models of whole cells: progress and challenges.Frontiers in cell and developmental biology · 2023
    Review
  4. Review
  5. Building Structural Models of a Whole Mycoplasma Cell.Journal of molecular biology · 2022
    Article
  6. Bayesian metamodeling of complex biological systems across varying representations.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Article
  8. Article
  9. Mesoscope: A Web-based Tool for Mesoscale Data Integration and Curation.MolVa : Workshop on Molecular Graphics and Visual Analysis of Molecular Data 2020 · 2020
    Article
  10. Article
  11. Emerging whole-cell modeling principles and methods.Current opinion in biotechnology · 2018
    Review
  12. Automated visualization of rule-based models.PLoS computational biology · 2017
    Article
  13. Review
  14. Review
  15. Toward Community Standards and Software for Whole-Cell Modeling.IEEE transactions on bio-medical engineering · 2016
    Article
  16. Guidelines for Reproducibly Building and Simulating Systems Biology Models.IEEE transactions on bio-medical engineering · 2016
    Article
  17. Review
  18. Databases for Microbiologists.Journal of bacteriology · 2015
    Review
  19. Article
  20. The future of whole-cell modeling.Current opinion in biotechnology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jonathan R KarrGraduate Program in Biophysics, Stanford University, 318 Campus Drive West, Stanford, CA 94305, USA.
Jayodita C Sanghvi
Derek N Macklin
Abhishek Arora
Markus W Covert
Stanford University · US

Funding

A Gene-Complete Computational Model of YeastDP1OD006413 · OD · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2009 to 2011
$2.4M
A Gene-Complete Computational Model of YeastDP1LM011510 · NLM · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2012 to 2013
$1.6M
PEARLS DisseminationR18DP001150 · DP · UNIVERSITY OF WASHINGTON · PI SNOWDEN, MARK · 2007 to 2009
$1.2M
NCCDPHP CDC HHS 5DP1LM01150-05NIH HHS DP1 OD006413NLM NIH HHS DP1 LM011510
6 · The paper itself

Abstract

Whole-cell models promise to greatly facilitate the analysis of complex biological behaviors. Whole-cell model development requires comprehensive model organism databases. WholeCellKB (http://wholecellkb.stanford.edu) is an open-source web-based software program for constructing model organism databases. WholeCellKB provides an extensive and fully customizable data model that fully describes individual species including the structure and function of each gene, protein, reaction and pathway. We used WholeCellKB to create WholeCellKB-MG, a comprehensive database of the Gram-positive bacterium Mycoplasma genitalium using over 900 sources. WholeCellKB-MG is extensively cross-referenced to existing resources including BioCyc, KEGG and UniProt. WholeCellKB-MG is freely accessible through a web-based user interface as well as through a RESTful web service.

Indexed as

Databases, GeneticModels, BiologicalBacterial ProteinsChromosomes, BacterialGenes, BacterialInternetMycoplasma genitaliumRNA, BacterialSoftwareUser-Computer InterfaceBacterial ProteinsRNA, Bacterial

Identifiers

PMID23175606
PMCPMC3531061
OpenAlexW2129075935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.