ArticleClinical and vaccine immunology : CVI2013
Incidence rates of clinical mastitis among Canadian Holsteins classified as high, average, or low immune responders.
Article in Clinical and vaccine immunology : CVI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors ofFrontiers in veterinary science · 2023Pooled it
- Prevalence and antimicrobial susceptibility profiles of Klebsiella Pneumoniea isolated from cases of bovine mastitis in Maya City, Eastern Hararghe, Ethiopia.BMC microbiology · 2026Article
- High immune responder cows have lower treatment risk and reduced milk loss during highly pathogenic avian influenza H5N1 outbreaks.JDS communications · 2026Article
- Comparative genomic analysis ofMicrobial genomics · 2025Article
- Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis.Communications biology · 2024Article
- Aleutian disease: Risk factors and ImmunAD strategy for genetic improvement of tolerance in American mink (Neogale vison).PloS one · 2024Article
- Discriminating bovine mastitis pathogens by combining loop-mediated isothermal amplification and amplicon-binding split trehalase assay.Frontiers in veterinary science · 2024Article
- Review
- RNA-Seq Analysis of Peripheral Whole Blood from Dairy Bulls with High and Low Antibody-Mediated Immune Responses-A Preliminary Study.Animals : an open access journal from MDPI · 2023Article
- The effects of timing of high immune response phenotyping in relation to weaning on immune responses of crossbred beef calves.Journal of animal science · 2023Article
- Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness.Nutrients · 2022Review
- Signaling differences in peripheral blood mononuclear cells of high and low vaccine responders prior to, and following, vaccination in piglets.Vaccine: X · 2022Article
- Advantages and Challenges of Differential Immune Cell Count Determination in Blood and Milk for Monitoring the Health and Well-Being of Dairy Cows.Veterinary sciences · 2022Review
- Immuno-phenotyping of Canadian beef cattle: adaptation of the high immune response methodology for utilization in beef cattle.Translational animal science · 2022Article
- Bovine innate immune phenotyping via a standardized whole blood stimulation assay.Scientific reports · 2021Article
- Comparative genomic analysis ofMicrobial genomics · 2021Article
- Draft Genome Sequences of 113 Escherichia coli Strains Isolated from Intramammary Infections in Dairy Cattle.Microbiology resource announcements · 2021Article
- A genome-wide association study for natural antibodies measured in blood of Canadian Holstein cows.BMC genomics · 2018Article
- Differential response of immune-related genes to peptidoglycan and lipoteichoic acid challengeVeterinary world · 2016Article
- Mouse models of mastitis - how physiological are they?International breastfeeding journal · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to compare the incidence rate of clinical mastitis (IRCM) between cows classified as high, average, or low for antibody-mediated immune responses (AMIR) and cell-mediated immune responses (CMIR). In collaboration with the Canadian Bovine Mastitis Research Network, 458 lactating Holsteins from 41 herds were immunized with a type 1 and a type 2 test antigen to stimulate adaptive immune responses. A delayed-type hypersensitivity test to the type 1 test antigen was used as an indicator of CMIR, and serum antibody of the IgG1 isotype to the type 2 test antigen was used for AMIR determination. By using estimated breeding values for these traits, cows were classified as high, average, or low responders. The IRCM was calculated as the number of cases of mastitis experienced over the total time at risk throughout the 2-year study period. High-AMIR cows had an IRCM of 17.1 cases per 100 cow-years, which was significantly lower than average and low responders, with 27.9 and 30.7 cases per 100 cow-years, respectively. Low-AMIR cows tended to have the most severe mastitis. No differences in the IRCM were noted when cows were classified based on CMIR, likely due to the extracellular nature of mastitis-causing pathogens. The results of this study demonstrate the desirability of breeding dairy cattle for enhanced immune responses to decrease the incidence and severity of mastitis in the Canadian dairy industry.
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