Evidence map›Paper›PMID 23175281›Full record

ReviewNature reviews. Molecular cell biology2012

Mitochondria: master regulators of danger signalling.

Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 398 papers.

0numbers the graph read from it
0cells of the map it votes in
398citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

398 citing papers in PubMed.

  1. A photothermal ablation strategy for orthotopic ovarian cancerInternational journal of pharmaceutics: X · 2026
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  3. bioRxiv : the preprint server for biology · 2026
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  6. Rutin attenuates liver fibrosis via the IRG1-itaconate-Nrf2 axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  7. Review
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  10. Review
  11. [Skin damage caused by optical radiation beyond UV].Dermatologie (Heidelberg, Germany) · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

338 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lorenzo GalluzziUniversité Paris V (Paris Descartes), 2 rue de l'École de Médecine, 75006 Paris, France.
Oliver Kepp
Guido Kroemer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria have developed not only the capacity to control distinct molecular cascades leading to cell death but also the ability to sense (and react to) multiple situations of cellular stress, including viral infection. In addition, mitochondria can emit danger signals that alert the cell or the whole organism of perturbations in homeostasis, hence promoting the induction of cell-intrinsic or systemic adaptive responses, respectively. As such, mitochondria can be considered as master regulators of danger signalling.

Indexed as

ApoptosisAnimalsHumansMiceMitochondriaSignal Transduction

Identifiers

PMID23175281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.