ArticleJournal of clinical microbiology2013
Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03197597 (EUpertstrain 4 Study of Bordetella Pertussis Isolates), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
EUpertstrain 4 Study of Bordetella Pertussis Isolates
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices - United States, 2019.MMWR. Morbidity and mortality weekly report · 2020Guideline
- Vaccine antigen-based genotyping ofMicrobiology spectrum · 2025Article
- Genomic characterization ofMicrobial genomics · 2023Article
- Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.Journal of clinical microbiology · 2023Article
- Macrolide susceptibility and molecular characteristics ofThe Journal of international medical research · 2022Article
- Fha DeficientIranian journal of public health · 2021Article
- Genome diversity and evolutionary characteristics of clinical isolates ofIranian journal of microbiology · 2020Article
- Article
- Pertactin-deficientEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Population dynamics and antigenic drift ofEmerging microbes & infections · 2019Article
- Strain variation and antigenic divergence among Bordetella pertussis circulating strains isolated from patients in Iran.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Genomic Sequencing of Bordetella pertussis for Epidemiology and Global Surveillance of Whooping Cough.Emerging infectious diseases · 2018Article
- Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015.Journal of clinical microbiology · 2018Article
- Epidemiology of pertussis in two Ibero-American countries with different vaccination policies: lessons derived from different surveillance systems.BMC public health · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Changes in Predominance of Pulsed-Field Gel Electrophoresis Profiles of Bordetella pertussis Isolates, United States, 2000-2012.Emerging infectious diseases · 2016Article
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Studying Bordetella pertussis populations by use of SNPeX, a simple high-throughput single nucleotide polymorphism typing method.Journal of clinical microbiology · 2015Article
- Sequence variation in virulence-related genes of Bordetella pertussis isolates from Poland in the period 1959-2013.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Between 1998 and 2009, Bordetella pertussis clinical isolates were collected during three periods, i.e., 1998 to 2001 (n = 102), 2004 to 2005 (n = 154), and 2007 to 2009 (n = 140), from nine countries with distinct vaccination programs, i.e., Denmark, Finland, France, Germany, The Netherlands, Norway, Poland, Sweden, and the United Kingdom. Pulsed-field gel electrophoresis (PFGE) analysis was performed according to standardized recommendations for epidemiological typing of B. pertussis. There were 81 different PFGE profiles, five of which (BpSR3, BpSR5, BpSR10, BpSR11, and BpSR12) were observed in 61% of the 396 isolates and shown to be predominant in almost all countries. The major profile, BpSR11, showed a decreasing trend from 25% to 30% in 1998 to 2005 to 13% in 2007 to 2009, and there were increases in BpSR3 and BpSR10 from 0% and 8% to 21% and 22%, respectively. One difference between these profiles is that BpSR11 contains isolates harboring the fim3-2 allele and BpSR3 and BpSR10 contain isolates harboring the fim3-1 allele. The total proportion of the five predominant profiles increased from 44% in 1998 to 2001 to 63% in 2004 to 2005 to 70% in 2007 to 2009. In conclusion, common PFGE profiles were identified in B. pertussis populations circulating in European countries with different vaccination programs and different vaccine coverages. These prevalent isolates contain the novel pertussis toxin promoter ptxP3 allele. However, there is evidence for diversifying selection between ptxP3 strains characterized by distinct PFGE profiles. This work shows that, even within a relatively short time span of 10 years, successful isolates which spread through Europe and cause large shifts in B. pertussis populations may emerge.
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