ArticleInternational journal of cancer2013
microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.Clinical and translational gastroenterology · 2018Pooled it
- The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis.TheScientificWorldJournal · 2014Pooled it
- Pooled it
- The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy.Frontiers in immunology · 2023Review
- A Novel Gene Signature Associated with Inflammatory Responses and Immune Status Assists in Prognosis and Intervention for Patients with HCC.Journal of inflammation research · 2022Article
- Construction and validation of a novel prognostic signature of microRNAs in lung adenocarcinoma.PeerJ · 2021Article
- Downregulation of microRNA-320a inhibits proliferation and induces apoptosis of retinoblastoma cells via targeting TUSC3.Experimental and therapeutic medicine · 2020Article
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- CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer.Oncology letters · 2017Article
- Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.Oncotarget · 2017Article
- MicroRNAs in esophageal squamous cell carcinoma: Potential biomarkers and therapeutic targets.Cancer biomarkers : section A of Disease markers · 2017Review
- Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China.Clinical & experimental metastasis · 2017Article
- A panel of autoantibodies against multiple tumor-associated antigens in the immunodiagnosis of esophageal squamous cell cancer.Cancer immunology, immunotherapy : CII · 2016Article
- The role of microRNA in esophageal squamous cell carcinoma.Journal of gastroenterology · 2016Review
- MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency.Oncotarget · 2016Article
- The role of cancer-associated fibroblasts in esophageal cancer.Journal of translational medicine · 2016Review
- MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
MicroRNAs (miRNAs) and inflammatory genes have a role in the initiation and development of esophageal squamous cell carcinoma (ESCC). In our study, we examined the potential of using miRNA and inflammatory gene expression patterns as prognostic classifiers for ESCC. Five miRNAs and 25 inflammatory-related genes were measured by quantitative reverse transcriptase PCR in tumor tissues and adjacent noncancerous tissues from 178 Chinese patients with ESCC. The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. These data were combined to generate a miRNA risk score that was significantly associated with worse prognosis (p = 0.0001), suggesting that these miRNAs may be useful prognostic classifiers for ESCC. To construct an inflammatory gene prognostic classifier, we divided the population into training (n = 124) and test cohorts (n = 54). The expression levels of CRY61, CTGF and IL-18 in tumor tissue and VEGF in adjacent noncancerous tissue were modestly associated with prognosis in the training cohort |Z-score| > 1.5 and were subsequently used to construct a Cox regression-based inflammatory risk score (IRS). IRS was significantly associated with survival in both the training cohort (p = 0.002) and the test cohort (p = 0.005). Furthermore, Cox regression models combining both miRNA risk score and IRS performed significantly better than models with either alone (p < 0.001 likelihood ratio test). Therefore, miRNA and inflammatory gene expression patterns, alone or in combination, have potential as prognostic classifiers for ESCC and may help to guide therapeutic decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.