Evidence map›Paper›PMID 23174993›Full record

ArticleHepatology (Baltimore, Md.)2013

Fibrates as adjuvant therapy for chronic cholestatic liver disease: its time has come.

Nisanne S Ghonem, James L Boyer

Registry-linked trialAbstract readEditorialComment
In one paragraph

Article in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03586674 (Fibrates), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03586674 phase2completednot on this mapstarted 2017, after this paper: background citation

Fibrates: An Adjuvant Therapy for Cholestasis In Pediatric Age Group

TypeinterventionalSponsorHoda A. AttaRan2017 to 2018Enrolled50ConditionsChronic CholestasisArmsLipanthyl, Ursogal
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. [Ursodeoxycholic acid combined with bezafibrate in the treatment of refractory primary biliary cholangitis: a meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Effects of Switching from Fenofibrate to Pemafibrate for Asymptomatic Primary Biliary Cholangitis.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Fibrates and cholestasis.Hepatology (Baltimore, Md.) · 2015
    Review
  16. Advances in pharmacotherapy for primary biliary cirrhosis.Expert opinion on pharmacotherapy · 2015
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nisanne S Ghonem
James L Boyer

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
MECHANISMS OF BILE SECRETION &CHOLESTASISR37DK025636 · NIDDK · YALE UNIVERSITY · PI BOYER, JAMES LORENZEN · 1990 to 2017
$9.7M
NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R37 DK025636
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anticholesteremic AgentsBezafibrateCholagogues and CholereticsFemaleHumansLiver Cirrhosis, BiliaryMaleUrsodeoxycholic AcidAnticholesteremic AgentsBezafibrateCholagogues and CholereticsUrsodeoxycholic Acid

Identifiers

PMID23174993
PMCPMC4048949

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.