ArticleNature chemistry2012
Twin disulfides for orthogonal disulfide pairing and the directed folding of multicyclic peptides.
Article in Nature chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Construction and Functional Evaluation of Cyclic Peptide-Based CAR T Cells in Tumor Models.Bio-protocol · 2026Article
- Discovering Serum Stable Protein-Protein Interaction Inhibitors with N‑Terminus-Capped Bicyclic Phage Libraries.JACS Au · 2026Article
- Directing the oxidative folding of disulfide-rich peptides for enhanced engineering and applications.Chemical science · 2025Review
- Decoupling sequence and structure.Nature reviews. Chemistry · 2025Article
- An innovative strategy for radical-mediated, bidirectional controlled disulfide exchange.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders.Nature communications · 2024Article
- Motifs for making tricycles.Nature chemical biology · 2023Article
- Selection and evolution of disulfide-rich peptidesChemical science · 2023Article
- Differential Peptide Multi-Macrocyclizations at the Surface of a Helical Foldamer Template.Angewandte Chemie (International ed. in English) · 2022Article
- Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery.Chemical science · 2022Article
- Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments.Journal of the American Chemical Society · 2021Article
- Approaches for peptide and protein cyclisation.Organic & biomolecular chemistry · 2021Review
- Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction.Journal of the American Chemical Society · 2020Article
- Article
- Angiotensin II-derived constrained peptides with antiplasmodial activity and suppressed vasoconstriction.Scientific reports · 2017Article
- Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Chemical science · 2017Article
- Disulfide-Mediated β-Strand Dimers: Hyperstable β-Sheets Lacking Tertiary Interactions and Turns.Journal of the American Chemical Society · 2015Article
- Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection.Antioxidants & redox signaling · 2014Review
- In vitro and cellular self-assembly of a Zn-binding protein cryptand via templated disulfide bonds.Journal of the American Chemical Society · 2013Article
- The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicyclic peptides are emerging as an exciting platform for drug and targeted ligand discovery owing to their expected greater target affinity/selectivity/stability versus linear or monocyclic peptides. However, although the precise pairing of cysteine residues in proteins is routinely achieved in nature, the rational pairing of cysteine residues within polypeptides is a long-standing challenge for the preparation of multicyclic species containing several disulfide bridges. Here, we present an efficient and straightforward approach for directing the intermolecular and intramolecular pairing of cysteine residues within peptides using a minimal CXC motif. Orthogonal disulfide pairing can be exploited in complex redox media to rationally produce dimeric peptides and bi/tricyclic peptides from fully reduced peptides containing 1-6 cysteine residues. This strategy, which does not rely on extensive manipulation of the primary sequence, post-translational modification or protecting groups, should greatly benefit the development of multicyclic peptide therapeutics and targeting ligands.
Indexed as
Identifiers
23174986What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.