ArticleMolecules (Basel, Switzerland)2012
An electrostatically crosslinked chitosan hydrogel as a drug carrier.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Hydrogel-Based Vitreous Substitutes.International journal of molecular sciences · 2025Review
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- A Thermosensitive and Degradable Chitin-Based Hydrogel as a Brucellosis Vaccine Adjuvant.Polymers · 2024Article
- Review
- Superporous hydrogels based on blends of chitosan and polyvinyl alcohol as a carrier for enhanced gastric delivery of resveratrol.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Cost-Efficient Production of the Sphingan WL Gum by Sphingomonas sp. WG Using Molasses and Sucrose as the Carbon Sources.Marine biotechnology (New York, N.Y.) · 2023Article
- Development of Chitosan/Gelatin-Based Hydrogels Incorporated with Albumin Particles.International journal of molecular sciences · 2022Article
- Advances in Biomaterials and Technologies for Vascular Embolization.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- A Cooperative Copper Metal-Organic Framework-Hydrogel System Improves Wound Healing in Diabetes.Advanced functional materials · 2017Article
- Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate.Pharmaceutical research · 2016Article
- The Alginate Layer for Improving Doxorubicin Release and Radiolabeling Stability of Chitosan Hydrogels.Nuclear medicine and molecular imaging · 2015Article
- Engineering Biomaterial-Drug Conjugates for Local and Sustained Chemotherapeutic Delivery.Bioconjugate chemistry · 2015Review
- Mercury(II) removal with modified magnetic chitosan adsorbents.Molecules (Basel, Switzerland) · 2013Article
- Synthesis and characterization of oil-chitosan composite spheres.Molecules (Basel, Switzerland) · 2013Article
- Dexamethasone-Loaded InjectableCell transplantationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable efforts have been devoted to control and maintain the sustained release of proteins. In this experiment, we used bovine serum albumin-fluorescein isothiocyanate (BSA-FITC) as a model protein to explore the potential utility of a chitosan and glycerol phosphate disodium salt (GP) hydrogel as a protein drug depot. The mixing of chitosan and GP solutions (0, 10, 20 and 30 wt%) formed a liquid at room temperature. At 37 °C, however, the chitosan/GP solutions formed hydrogels through an electrostatic crosslinking process. This electrostatic interaction between the chitosan, cationic amine group, and GP, anionic phosphate group, was confirmed by the changes of zeta potentials and particle sizes of this solution. The electrostatic interaction depended both on the GP ratios in chitosan and the incubation time of chitosan/GP solutions. Furthermore, BSA-FITC-loaded chitosan/GP hydrogels were examined for their ability as potential depots for the BSA drugs. Hence, when observed, the BSA-FITC-loaded chitosan/GP hydrogels showed an in vitro sustained release profile of BSA up to 14 days. Collectively, our results show that the chitosan/GP hydrogels described here, can serve as depots for BSA drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.