Evidence map›Paper›PMID 23174301›Full record

ArticleCurrent biology : CB2012

Organelle biogenesis: en BLOC exchange for RAB32 and RAB38.

Michael S Marks

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Two Novel HomozygousLife (Basel, Switzerland) · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael S MarksDepartment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. marksm@mail.med.upenn.edu
University of Pennsylvania · US

Funding

Hermansky Pudlak Syndrome &melanosome formationR01EY015625 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Michael S Marks · 2004 to 2026
$9.2M
Platelet granule biogenesis in health and diseaseR21HL096865 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MARKS, MICHAEL S · 2010 to 2011
$400k
NEI NIH HHS R01 EY015625NHLBI NIH HHS R21 HL096865
6 · The paper itself

Abstract

Prominent subtypes of the genetic disorder Hermansky-Pudlak syndrome result from defects in a mysterious protein complex, BLOC-3. New work identifies BLOC-3 as a guanine nucleotide exchange factor for two RAB GTPases previously implicated in lysosome-related organelle biogenesis.

Indexed as

AnimalsCell Line, TumorGene Expression RegulationGuanine Nucleotide Exchange FactorsHermanski-Pudlak SyndromeHumansMelanocytesMiceMultiprotein ComplexesOrganellesProtein Transportrab GTP-Binding ProteinsRatsGuanine Nucleotide Exchange FactorsMultiprotein Complexesrab GTP-Binding Proteins

Identifiers

PMID23174301
PMCPMC3513372
OpenAlexW2086681046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.