ArticleBMC veterinary research2012
Isolation and phylogenetic analysis of orf virus from the sheep herd outbreak in northeast China.
Article in BMC veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Vertical transmission of Orf virus in goats and its prevention.Veterinary research · 2026Article
- Article
- The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China's host landscapes.Virology journal · 2025Article
- Recombinant Orf virus induced antibody production against capsid protein of porcine circovirus type 3 in mice.Veterinary research communications · 2023Article
- The whole genomic analysis of the Orf virus strains ORFV-SC and ORFV-SC1 from the Sichuan province and their weak pathological response in rabbits.Functional & integrative genomics · 2023Article
- ORFV infection enhances CXCL16 secretion and causes oncolysis of lung cancer cells through immunogenic apoptosis.Frontiers in cellular and infection microbiology · 2022Article
- The Combined Use of Orf Virus and PAK4 Inhibitor Exerts Anti-tumor Effect in Breast Cancer.Frontiers in microbiology · 2022Article
- Article
- An association of Orf virus infection among sheep and goats with herd health programme in Terengganu state, eastern region of the peninsular Malaysia.BMC veterinary research · 2019Article
- Molecular characterization of Orf virus isolates from Kodai hills, Tamil Nadu, India.Veterinary world · 2019Article
- Dermatopathology of Orf Virus (Malaysian Isolates) in Mice Experimentally Inoculated at Different Sites with and without Dexamethasone Administration.Journal of pathogens · 2018Article
- Orf Virus Encoded Protein ORFV119 Induces Cell Apoptosis Through the Extrinsic and Intrinsic Pathways.Frontiers in microbiology · 2018Article
- Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus.Oncotarget · 2017Article
- The whole genomic analysis of orf virus strain HN3/12 isolated from Henan province, central China.BMC veterinary research · 2017Article
- Molecular characterization of orf virus from sheep and goats in Ethiopia, 2008-2013.Virology journal · 2016Article
- Phylogenetic analysis of three orf virus strains isolated from different districts in Shandong Province, East China.The Journal of veterinary medical science · 2016Article
- Identification and Characterization of a Cleavage Site in the Proteolysis of Orf Virus 086 Protein.Frontiers in microbiology · 2016Article
- Isolation and phylogenetic analysis of caprine Orf virus in Malaysia.Virusdisease · 2015Article
- Isolation and Characterization of Monoclonal Antibodies Against a Virion Core Protein of Orf Virus Strain NA1/11 As Potential Diagnostic Tool for Orf Viruses.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2015Article
- Identification and molecular characterization of Orf virus in Argentina.Virus genes · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrf is a zoonotic and epitheliotrophic contagious disease that mainly affects sheep, goats, wild ruminants, and humans with a worldwide distribution. To date, there is little information on the characterization of ORFV strains that are endemic in Mainland China. In addition, the relationship between the severity of disease and the molecular profile of ORFV strains has not been fully elucidated.
resultsFrom the recent outbreak of a sheep herd in Nongan, northeast of China, the novel orf virus (ORFV) strain NA1/11 was successfully isolated. Western blot analysis indicated that the NA1/11 strain cross reacts with monoclonal antibody A3 and infected sheep ORFV antiserum. The purified virions revealed the typical ovoid shape when observed by atomic force microscopy. To determine the genetic characteristics of the NA1/11 strain, the sequences of ORFV011 (B2L), ORFV059 (F1L), ORFV109, ORFV110 and ORFv132 (VEGF) genes were amplified and compared with reference parapoxvirus strains. Non-metric multidimensional scaling (nMDS) was performed to analyze the nucleotide similarities between different ORFV strains.
conclusionsPhylogenetic analysis based on ORFV 011 nucleotide sequences showed that the NA1/11strain was closely related to Xinjiang and Gansu strains. ORFV110 and ORFV132 genes are highly variable. The results revealed that precise phylogenetic analysis might provide evidence for genetic variation and movement of circulating ORFV strains in Northeast China. In addition, nMDS analysis showed that geographic isolation and animal host are likely major factors resulting in genetic differences between ORFV strains.
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