Evidence map›Paper›PMID 23173776›Full record

ReviewBMC infectious diseases2012

Molecular diagnostic and predictive tests in the evolution of chronic hepatitis C anti-viral therapies.

Giuseppe Colucci

Abstract readReview
In one paragraph

Review in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Giuseppe ColucciRoche Diagnostics, GCS, CH 6343 Rotkreuz, Switzerland. giuseppe.colucci.gc1@roche.com

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the discovery of HCV, polymerase chain reaction (PCR) has significantly contributed to the understanding of the virus life cycle and its replicative kinetics during anti-viral therapy. Parallel to the progression of dual and triple combination treatment, real-time PCR molecular tests have constantly improved in their ability to monitor viral load and drive personalized management schedules. The current sensitivity, accuracy and dynamic range of the available assays fulfil the requirement of "companion diagnostics" and support the development of new directly acting antiviral (DAA)-based regimens.

Indexed as

Antiviral AgentsHepacivirusHepatitis C, ChronicHumansPathology, MolecularPolymerase Chain ReactionViral LoadAntiviral Agents

Identifiers

PMID23173776
PMCPMC3495636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.