ArticleTransplant infectious disease : an official journal of the Transplantation Society2013
Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.
Article in Transplant infectious disease : an official journal of the Transplantation Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines.World journal of emergency surgery : WJES · 2021Guideline
- Prevalence of Clostridium difficile infection among solid organ transplant recipients: a meta-analysis of published studies.PloS one · 2015Pooled it
- Emerging therapies and diagnostic innovations for multidrug-resistant infections in kidney allograft recipients: Challenges and future directions.World journal of nephrology · 2026Review
- Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Clinical and Pharmacoeconomic evaluation of Fidaxomicin in patients over 65 years of age and immunocompromised patients with recurrent and refractory Clostridioides difficile infection.BMC infectious diseases · 2026Article
- Screening and targeted prophylaxis for Clostridioides difficile infection.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025Article
- Review
- Preservation of the Innate Immune Response toOpen forum infectious diseases · 2023Article
- Incidence and Outcomes Associated With Clostridioides difficile Infection in Solid Organ Transplant Recipients.JAMA network open · 2021Article
- Article
- Incidence Rate of Post-Kidney Transplant Infection: A Retrospective Cohort Study Examining Infection Rates at a Large Canadian Multicenter Tertiary-Care Facility.Canadian journal of kidney health and disease · 2018Article
- Role of the leukocyte response in normal and immunocompromised host after Clostridium difficile infection.Anaerobe · 2017Review
- Article
- Antibiotic therapy and Clostridium difficile infection - primum non nocere - first do no harm.Infection and drug resistance · 2015Article
- Clostridium difficile Infection (CDI) in Solid Organ and Hematopoietic Stem Cell Transplant Recipients.Current infectious disease reports · 2014Article
- Community-acquired Clostridium difficile infection: an increasing public health threat.Infection and drug resistance · 2014Review
- Clostridium difficile infection after adult autologous stem cell transplantation: a multicenter study of epidemiology and risk factors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundWe sought to describe the epidemiology and risk factors for Clostridium difficile infection (CDI) among kidney transplant recipients (KTR) between 1 January 2008 and 31 December 2010.
methodsA single-institution retrospective study was conducted among all adult KTR with CDI, defined as a positive test for C. difficile by a cell cytotoxic assay for C. difficile toxin A or B or polymerase chain reaction test for toxigenic C. difficile.
resultsAmong 603 kidney transplants performed between 1 January 2008 and 31 December 2010, 37 (6.1%) patients developed CDI: 12 (of 128; 9.4%) high-risk (blood group incompatible and/or anti-human leukocyte antigen donor-specific antibodies) vs. 25 (of 475; 5.3%, P = 0.08) standard-risk patients. The overall rate of CDI increased from 3.7% in 2008 to 9.4% in 2010 (P = 0.05). The median time to CDI diagnosis was 9 days, with 27 (73.0%) patients developing CDI within the first 30 days after their transplant, and 14 (51.8%) developing CDI within 7 days. A case-control analysis of 37 CDI cases and 74 matched controls demonstrated the following predictors for CDI among KTR: vancomycin-resistant Enterococcus colonization before transplant (odds ratio [OR]: 3.6, P = 0.03), receipt of an organ from Centers for Disease Control high-risk donor (OR: 5.9, P = 0.006), and administration of high-risk antibiotics within 30 days post transplant (OR: 6.6, P = 0.001).
conclusionsCDI remains a common early complication in KTR, with rates steadily increasing during the study period. Host and transplant-related factors and exposure to antibiotics appeared to significantly impact the risk for CDI among KTR.
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