ArticleBMC cancer2012
Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Systemic adiponectin levels in colorectal cancer and adenoma: a systematic review and meta-analysis.International journal of obesity (2005) · 2023Pooled it
- Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis.BioMed research international · 2016Pooled it
- An Updated Review of Resistin and Colorectal Cancer.Cureus · 2024Review
- Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis.Journal of cell communication and signaling · 2023Article
- Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences.PloS one · 2019Article
- NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development.Frontiers in immunology · 2018Review
- Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity.Frontiers in endocrinology · 2018Article
- Low circulating total adiponectin, especially its non-high-molecular weight fraction, represents a promising risk factor for colorectal cancer: a meta-analysis.OncoTargets and therapy · 2018Article
- Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer.World journal of gastroenterology · 2017Article
- Sex difference in EGFR pathways in mouse kidney-potential impact on the immune system.BMC genetics · 2016Article
- Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer.International journal of colorectal disease · 2016Article
- Circulating adipokine levels and prognostic value in septic patients.Journal of inflammation (London, England) · 2016Article
- Mechanisms by Which Pleiotropic AmphiphilicCurrent colorectal cancer reports · 2014Article
- The risk of colonic adenomas and colonic cancer in obesity.Best practice & research. Clinical gastroenterology · 2014Review
- Mechanisms linking excess adiposity and carcinogenesis promotion.Frontiers in endocrinology · 2014Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pathogenesis and progression. The aim of this study was to analyze plasma concentrations of several adipose tissue expressed hormones in colorectal cancer patients (CRC) and morbidly obese (MO) patients and to compare these concentrations to clinicopathological parameters.
methodsPlasma concentrations of adiponectin, resistin, leptin, active plasminogen activator inhibitor (PAI)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-1 alpha, and tumor necrosis factor (TNF)-alpha were determined in 67 patients operated on for CRC (31 rectal cancers, 36 colon cancers), 37 patients operated on for morbid obesity and 60 healthy blood donors (BD).
resultsCompared to BD, leptin concentrations were lowered in CRC patients whereas those of MO patients were elevated. Adiponectin concentrations were only lowered in MO patients. Concentrations of MCP-1, PAI-1, and IL-1 alpha were elevated in both CRC and MO patients, while resistin and TNF-alpha were similarly expressed in MO and CRC patients compared to BD. Resistin concentrations positively correlated with tumor staging (p<0.002) and grading (p=0.015) of rectal tumor patients.
conclusionsThe results suggest that both MO and CRC have low-grade inflammation as part of their etiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.