ArticleBMC genomics2012
Downy mildew resistance induced by Trichoderma harzianum T39 in susceptible grapevines partially mimics transcriptional changes of resistant genotypes.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 156 citations in OpenAlex.
- Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola).Pest management science · 2026Article
- Choline pelargonate treatments decreased downy mildew and powdery mildew symptoms with negligible effects on grapevine phyllosphere micro-organisms.FEMS microbiology ecology · 2026Article
- The grapevine LysM receptor kinase VvLYK4-2 is a key player in chitosan-triggered immune responses.Horticulture research · 2026Article
- Effects of Trichoderma treatments on the phenolic and sensory quality of Aglianico grapes and wine.Journal of the science of food and agriculture · 2026Article
- The assembly and annotation of two teinturier grapevine varieties, Dakapo and Rubired.GigaByte (Hong Kong, China) · 2025Article
- The Transcriptional Landscape of Berry Skin in Red and White PIWI ("Pilzwiderstandsfähig") Grapevines Possessing QTLs for Partial Resistance to Downy and Powdery Mildews.Plants (Basel, Switzerland) · 2024Article
- Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.PloS one · 2024Article
- Interactions between plant-beneficial microorganisms in a consortium: Streptomyces microflavus and Trichoderma harzianum.Microbial biotechnology · 2023Article
- Unravelling molecular mechanisms involved in resistance priming against downy mildew (Plasmopara viticola) in grapevine (Vitis vinifera L.).Scientific reports · 2023Article
- Mechanisms of systemic resistance to pathogen infection in plants and their potential application in forestry.BMC plant biology · 2023Review
- The Biocontrol Potential of EndophyticPathogens (Basel, Switzerland) · 2022Article
- Transcriptome Analysis ofGenes · 2022Article
- Leaf Polyphenolic Profile as a Determinant of Croatian Native Grapevine Varieties' Susceptibility toFrontiers in plant science · 2022Article
- Grapevine response to aFrontiers in plant science · 2022Article
- Review
- Article
- Trichoderma spp. volatile organic compounds protect grapevine plants by activating defense-related processes against downy mildew.Physiologia plantarum · 2021Article
- Integration of early disease-resistance phenotyping, histological characterization, and transcriptome sequencing reveals insights into downy mildew resistance in impatiens.Horticulture research · 2021Article
- Plasmopara viticola infection affects mineral elements allocation and distribution in Vitis vinifera leaves.Scientific reports · 2020Article
- Genome Sequencing ofPathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDowny mildew, caused by Plasmopara viticola, is one of the most severe diseases of grapevine and is commonly controlled by fungicide treatments. The beneficial microorganism Trichoderma harzianum T39 (T39) can induce resistance to downy mildew, although the molecular events associated with this process have not yet been elucidated in grapevine. A next generation RNA sequencing (RNA-Seq) approach was used to study global transcriptional changes associated with resistance induced by T39 in Vitis vinifera Pinot Noir leaves. The long-term aim was to develop strategies to optimize the use of this agent for downy mildew control.
resultsMore than 14.8 million paired-end reads were obtained for each biological replicate of T39-treated and control leaf samples collected before and 24 h after P. viticola inoculation. RNA-Seq analysis resulted in the identification of 7,024 differentially expressed genes, highlighting the complex transcriptional reprogramming of grapevine leaves during resistance induction and in response to pathogen inoculation. Our data show that T39 has a dual effect: it directly modulates genes related to the microbial recognition machinery, and it enhances the expression of defence-related processes after pathogen inoculation. Whereas several genes were commonly affected by P. viticola in control and T39-treated plants, opposing modulation of genes related to responses to stress and protein metabolism was found. T39-induced resistance partially inhibited some disease-related processes and specifically activated defence responses after P. viticola inoculation, causing a significant reduction of downy mildew symptoms.
conclusionsThe global transcriptional analysis revealed that defence processes known to be implicated in the reaction of resistant genotypes to downy mildew were partially activated by T39-induced resistance in susceptible grapevines. Genes identified in this work are an important source of markers for selecting novel resistance inducers and for the analysis of environmental conditions that might affect induced resistance mechanisms.
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