ArticleAmerican journal of cardiovascular disease2012
Genetic epidemiology of left ventricular hypertrophy.
Article in American journal of cardiovascular disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Left ventricular parameters and mass indexing methods in cardiac magnetic resonance imaging in prediction of major adverse cardiovascular events and mortality.Quantitative imaging in medicine and surgery · 2026Article
- Association between Hypertension with and without Left Ventricular Hypertrophy and the Expression of a Panel of microRNAs in an Iranian Population.Research in heart yield and translational medicine · 2025Article
- Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan.Frontiers in genetics · 2022Article
- Pregestational diabetes alters cardiac structure and function of neonatal rats through developmental plasticity.Frontiers in cardiovascular medicine · 2022Article
- Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention.Frontiers in cardiovascular medicine · 2021Review
- Cardiovascular Risk Factors Track From Mother to Child.Journal of the American Heart Association · 2018Article
- XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Genetically determined pattern of left ventricular function in normal and hypertensive hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy.International journal of molecular sciences · 2018Review
- A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy.BMC medical genomics · 2018Article
- Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography.Journal of hypertension · 2016Article
- Intrafamilial aggregation and heritability of left ventricular geometric remodeling is independent of cardiac mass in families of African ancestry.American journal of hypertension · 2015Article
- The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients.Journal of translational medicine · 2015Article
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- Serum osteopontin, but not OPN gene polymorphism, is associated with LVH in essential hypertensive patients.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Dual Linkage of a Locus to Left Ventricular Mass and a Cardiac Gene Co-Expression Network Driven by a Chromosome Domain.Frontiers in cardiovascular medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular (LV) hypertrophy is a strong independent predictor of increased cardiovascular morbidity and mortality in clinical and population-based samples. Clinical and hemodynamic stimuli to LV hypertrophy induce not only an increase in cardiac mass and wall thickness but also a fundamental reconfiguration of the protein, cellular and molecular components of the myocardium. Several studies have indicated that LV mass is influenced by genetic factors. The substantial heritability (h(2)) for LV mass in population-based samples of varying ethnicity indicates robust genetic influences on LV hypertrophy. Genome-wide linkage and association studies in diverse populations have been performed to identify genes influencing LV mass, and although several chromosomal regions have been found to be significantly associated with LV mass, the specific genes and functional variants contained in these chromosomal regions have yet to be identified. In addition, multiple studies have tried to link single-nucleotide polymorphisms (SNPs) in regulatory and pathway genes with common forms of LV hypertrophy, but there is little evidence that these genetic variations are functional. Up to this point in time, the results obtained in genetic studies are of limited clinical value. Much of the heritability remains unexplained, the identity of the underlying gene pathways, genes, and functional variants remains unknown, and the promise of genetically-based risk prediction and personalized medicine remain unfulfilled. However, molecular biological technologies continue to improve rapidly, and the long-term potential of sophisticated genetic investigations using these modern genomic technologies, coupled with smart study designs, remains intact. Ultimately, genetic investigations offer much promise for future prevention, early intervention and treatment of this major public health issue.
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Identifiers
23173100PMC3499934W12248668What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.