ArticleG3 (Bethesda, Md.)2012
Escherichia coli lacking RpoS are rare in natural populations of non-pathogens.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024Review
- A Broad Continuum of E. coli Traits in Nature Associated with the Trade-off Between Self-preservation and Nutritional Competence.Microbial ecology · 2022Article
- Selection-Driven Gene Inactivation in Salmonella.Genome biology and evolution · 2020Article
- Assembly and Characterization of a Pathogen Strain Collection for Produce Safety Applications: Pre-growth Conditions Have a Larger Effect on Peroxyacetic Acid Tolerance Than Strain Diversity.Frontiers in microbiology · 2019Article
- A network of regulators promotes dehydration tolerance in Escherichia coli.Environmental microbiology · 2018Article
- Genome-Wide Transcriptional Response to Varying RpoS Levels in Escherichia coli K-12.Journal of bacteriology · 2017Article
- Bacterial virulence phenotypes ofScience translational medicine · 2017Article
- Article
- The General Stress Response Is Conserved in Long-Term Soil-Persistent Strains of Escherichia coli.Applied and environmental microbiology · 2016Article
- Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatedness.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073.PloS one · 2015Article
- Mutations in global regulators lead to metabolic selection during adaptation to complex environments.PLoS genetics · 2014Article
- The rpoS gene is predominantly inactivated during laboratory storage and undergoes source-sink evolution in Escherichia coli species.Journal of bacteriology · 2014Article
- Fitness, stress resistance, and extraintestinal virulence in Escherichia coli.Infection and immunity · 2013Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
The alternative sigma factor RpoS controls a large regulon that allows E. coli to respond to a variety of stresses. Mutations in rpoS can increase rates of nutrient acquisition at the cost of a decrease in stress resistance. These kinds of mutations evolve rapidly under certain laboratory conditions where nutrient acquisition is especially challenging. The frequency of strains lacking RpoS in natural populations of E. coli is less clear. Such strains have been found at frequencies over 20% in some collections of wild isolates. However, laboratory handling can select for RpoS-null strains and may have affected some of these strain collections. Other studies have included an unknown diversity of strains or only used a phenotypic proxy as a measure of RpoS levels. We directly measured RpoS levels in a collection of E. coli that includes the full diversity of the species and that was handled in a manner to minimize the potential for laboratory evolution. We found that only 2% of strains produce no functional RpoS. Comparison of these strains in multiple labs shows that these rpoS mutations occurred in the laboratory. Earlier studies reporting much higher levels of RpoS polymorphism may reflect the storage history of the strains in laboratories rather than true frequency of such strains in natural populations.
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Registered trials
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