ArticleSoft matter2011
Impact of sterol tilt on membrane bending rigidity in cholesterol and 7DHC-containing DMPC membranes.
Article in Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Effective Parameters Controlling Sterol Transfer: A Time-Resolved Small-Angle Neutron Scattering Study.The Journal of membrane biology · 2022Article
- Investigation ofInternational journal of molecular sciences · 2021Article
- Solid-State NMR of highlyMethods (San Diego, Calif.) · 2018Article
- Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations.BMC bioinformatics · 2016Article
- Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases.Journal of chemical theory and computation · 2013Article
- How sterol tilt regulates properties and organization of lipid membranes and membrane insertions.Chemistry and physics of lipids · 2013Review
- Lipid sorting by ceramide and the consequences for membrane proteins.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cholesterol is so essential to the proper function of mammalian cell membranes that even strikingly small inborn errors in cholesterol synthesis can be devastating. Here we combine molecular dynamics simulations with small angle x-ray diffraction experiments to compare mixed sterol/DMPC membranes over a wide range of sterol compositions for two types of sterols: cholesterol and its immediate metabolic precursor 7DHC, that differs from cholesterol by one double bond. We find that while most membrane properties are only slightly affected by the replacement of one sterol by the other, the tilt degree of freedom, as gauged by the tilt modulus, is significantly larger for cholesterol than for 7DHC over a large range of concentrations. In silico mutations of one sterol into the other further support these findings. Moreover, bending rigidities calculated from simulations and estimated in experiments show that cholesterol stiffens membranes to a larger extent than 7DHC. We discuss the possible mechanistic link between sterol tilt and the way it impacts the membrane mechanical properties, and comment on how this link may shed light on the way replacement of cholesterol by 7DHC leads to disease.
Identifiers
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Registered trials
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