ReviewVascular health and risk management2012
Treatment of prehypertension: lifestyle and/or medication.
Review in Vascular health and risk management, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03764020 (A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP)
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence, awareness, treatment, and control of hypertension in Nigeria in 1995 and 2020: A systematic analysis of current evidence.Journal of clinical hypertension (Greenwich, Conn.) · 2021Pooled it
- Effect of Yoga on Blood Pressure in Prehypertension: A Systematic Review and Meta-Analysis.TheScientificWorldJournal · 2021Pooled it
- Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Trial
- Prehypertension in young physically active adults: early vascular alterations and implications for exercise-intensity prescription.Frontiers in cardiovascular medicine · 2026Article
- Article
- Metabolomic profiling reveals key metabolites associated with hypertension progression.Frontiers in cardiovascular medicine · 2024Article
- Risk reduction intervention for raised blood pressure (REVERSE): protocol for a mixed-methods feasibility study.BMJ open · 2023Article
- Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms.Molecular nutrition & food research · 2022Review
- Hypertensive patients' knowledge and practices on lifestyle modification in Extension 6, Middelburg.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022Article
- Association between dietary total antioxidant capacity and hypertension in Iranian Kurdish women.BMC women's health · 2022Article
- Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea.Journal of Zhejiang University. Science. B · 2021Article
- Plasma concentrations and ACE-inhibitory effects of tryptophan-containing peptides from whey protein hydrolysate in healthy volunteers.European journal of nutrition · 2020Article
- Article
- Sympathoexcitation and impaired arterial baroreflex sensitivity are linked to vascular inflammation in individuals with elevated resting blood pressure.Physiological reports · 2019Article
- Variability of metabolic risk factors associated with prehypertension in males and females: a cross-sectional study in China.Archives of medical science : AMS · 2018Article
- Effects of tryptophan-containing peptides on angiotensin-converting enzyme activity and vessel tone ex vivo and in vivo.European journal of nutrition · 2018Article
- Biotechnological production of the angiotensin-converting enzyme inhibitory dipeptide isoleucine-tryptophan.Engineering in life sciences · 2018Article
- Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension.Arquivos brasileiros de cardiologia · 2018Article
- Prehypertension and psychosocial risk factors among university students in ASEAN countries.BMC cardiovascular disorders · 2017Article
- Diastolic pressure above optimal is the most important predictor of subsequent hypertension in normotensive patients younger 50 years.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prehypertension is a warning to individuals with resting blood pressures between 120/80 mmHg and 139/89 mmHg of an insidious progression of blood pressure towards hypertensive levels (≥ 140/90 mmHg). Prehypertension is associated with increased cardiovascular risk and end organ damage compared with individuals who are normotensive. This review primarily focuses on internal and external factors associated with the prevalence of prehypertension. Elucidating all of the factors associated with a rise in resting blood pressure and comparing the effects of medication versus lifestyle changes may aid the clinician in developing a preventive and/or treatment strategy for each individual.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.