ArticleDevelopment (Cambridge, England)2012
The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 85 citations in OpenAlex.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Challenges and progress in RNA velocity: Comparative analysis across multiple biological contexts.PLoS computational biology · 2026Article
- Rapgef1 paralog-mediated regulation of Wnt/β-catenin signaling orchestrates early embryo tissue patterning and morphogenesis.Cell communication and signaling : CCS · 2026Article
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Approximated gene expression trajectories for gene regulatory network inference on cell tracks.iScience · 2024Article
- Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome.Human genomics · 2024Article
- Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum.Molecular biology and evolution · 2023Article
- Article
- Automated time-lapse data segmentation reveals in vivo cell state dynamics.Science advances · 2023Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Mesoderm induction and patterning: Insights from neuromesodermal progenitors.Seminars in cell & developmental biology · 2022Review
- The unappreciated generative role of cell movements in pattern formation.Royal Society open science · 2022Review
- Dand5 is involved in zebrafish tailbud cell movement.Frontiers in cell and developmental biology · 2022Article
- Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus.Development (Cambridge, England) · 2021Article
- The zebrafish presomitic mesoderm elongates through compaction-extension.Cells & development · 2021Article
- Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development.Journal of Korean Neurosurgical Society · 2021Article
- Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development.Development (Cambridge, England) · 2020Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Somites are formed from the presomitic mesoderm (PSM) and give rise to the axial skeleton and skeletal muscles. The PSM is dynamic; somites are generated at the anterior end, while the posterior end is continually renewed with new cells entering from the tailbud progenitor region. Which genes control the conversion of tailbud progenitors into PSM and how is this process coordinated with cell movement? Using loss- and gain-of-function experiments and heat-shock transgenics we show in zebrafish that the transcription factor Mesogenin 1 (Msgn1), acting with Spadetail (Spt), has a central role. Msgn1 allows progression of the PSM differentiation program by switching off the progenitor maintenance genes ntl, wnt3a, wnt8 and fgf8 in the future PSM cells as they exit from the tailbud, and subsequently induces expression of PSM markers such as tbx24. msgn1 is itself positively regulated by Ntl/Wnt/Fgf, creating a negative-feedback loop that might be crucial to regulate homeostasis of the progenitor population until somitogenesis ends. Msgn1 drives not only the changes in gene expression in the nascent PSM cells but also the movements by which they stream out of the tailbud into the PSM. Loss of Msgn1 reduces the flux of cells out of the tailbud, producing smaller somites and an enlarged tailbud, and, by delaying exhaustion of the progenitor population, results in supernumerary tail somites. Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.