ArticleAnnals of the rheumatic diseases2013
Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.
Article in Annals of the rheumatic diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors.Arthritis & rheumatology (Hoboken, N.J.) · 2016Pooled it
- The prevalence of systemic sclerosis is increased among patients with alopecia areata: a population-based study.Immunologic research · 2019Trial
- Lack of association of the PLD4 SNP rs2841277 with systemic sclerosis in a European American population.Scientific reports · 2024Article
- Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis.Archives of Razi Institute · 2022Article
- The Immunogenetics of Systemic Sclerosis.Advances in experimental medicine and biology · 2022Article
- Determination of T Cell Responses in Thai Systemic Sclerosis Patients.Journal of immunology research · 2022Article
- Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus.Arthritis research & therapy · 2021Article
- Updates on genetics in systemic sclerosis.Inflammation and regeneration · 2021Review
- IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.Bioscience reports · 2020Article
- Current perspectives on the immunopathogenesis of systemic sclerosis.ImmunoTargets and therapy · 2016Review
- Genetics of systemic sclerosis: recent advances.Current opinion in rheumatology · 2015Review
- Genetics, Epigenetics, and Genomics of Systemic Sclerosis.Rheumatic diseases clinics of North America · 2015Review
- Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report.World journal of gastroenterology · 2015Article
- Genetic association of IL-21 polymorphisms with dilated cardiomyopathy in a Han Chinese population.Herz · 2015Article
- Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.PLoS computational biology · 2015Article
- Pathogenesis of Systemic Sclerosis.Frontiers in immunology · 2015Review
- Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran.American journal of clinical and experimental immunology · 2015Article
- Personalized medicine in systemic sclerosis: facts and promises.Current rheumatology reports · 2014Review
- Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.The open rheumatology journal · 2014Article
- Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins.Cellular and molecular life sciences : CMLS · 2004Review
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 9 countries.
Funding
Abstract
objectiveThe interleukin 2 (IL-2) and interleukin 21 (IL-21) locus at chromosome 4q27 has been associated with several autoimmune diseases, and both genes are related to immune system functions. The aim of this study was to evaluate the role of the IL-2/IL-21 locus in systemic sclerosis (SSc). PATIENTS AND
methodsThe case control study included 4493 SSc Caucasian patients and 5856 healthy controls from eight Caucasian populations (Spain, Germany, The Netherlands, USA, Italy, Sweden, UK and Norway). Four single nucleotide polymorphisms (rs2069762, rs6822844, rs6835457 and rs907715) were genotyped using TaqMan allelic discrimination assays.
resultsWe observed evidence of association of the rs6822844 and rs907715 variants with global SSc (pc=6.6E-4 and pc=7.2E-3, respectively). Similar statistically significant associations were observed for the limited cutaneous form of the disease. The conditional regression analysis suggested that the most likely genetic variation responsible for the association was the rs6822844 polymorphism. Consistently, the rs2069762A-rs6822844T-rs6835457G-rs907715T allelic combination showed evidence of association with SSc and limited cutaneous SSc subtype (pc=1.7E-03 and pc=8E-4, respectively).
conclusionsThese results suggested that the IL-2/IL-21 locus influences the genetic susceptibility to SSc. Moreover, this study provided further support for the IL-2/IL-21 locus as a common genetic factor in autoimmune diseases.
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