ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Tissue-specific responses to aberrant FGF signaling in complex head phenotypes.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Craniofacial endotype of obstructive sleep apnea: Spatial matrix hypothesis.Sleep & breathing = Schlaf & Atmung · 2026Review
- Regional variability in craniofacial stiffness: a study in normal and Crouzon mice during postnatal development.Biomechanics and modeling in mechanobiology · 2025Article
- Synchondrosis fusion contributes to the progression of postnatal craniofacial dysmorphology in syndromic craniosynostosis.Journal of anatomy · 2023Article
- A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium.eLife · 2022Article
- Meckel's Cartilage in Mandibular Development and Dysmorphogenesis.Frontiers in genetics · 2022Article
- Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.Disease models & mechanisms · 2019Article
- Craniofacial skeletal response to encephalization: How do we know what we think we know?American journal of physical anthropology · 2019Article
- Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects.Development (Cambridge, England) · 2018Article
- Predicting calvarial growth in normal and craniosynostotic mice using a computational approach.Journal of anatomy · 2018Article
- Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face.Scientific reports · 2018Article
- C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model.PloS one · 2018Article
- Choanal Atresia and Craniosynostosis: Development and Disease.Plastic and reconstructive surgery · 2018Review
- Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome.International journal of biological sciences · 2017Article
- Integration of Brain and Skull in Prenatal Mouse Models of Apert and Crouzon Syndromes.Frontiers in human neuroscience · 2017Article
- Developmental and Evolutionary Significance of the Zygomatic Bone.Anatomical record (Hoboken, N.J. : 2007) · 2016Article
- Understanding craniosynostosis as a growth disorder.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Article
- Performance of single and multi-atlas based automated landmarking methods compared to expert annotations in volumetric microCT datasets of mouse mandibles.Frontiers in zoology · 2015Article
- Experimental Fusion of Contrast Enhanced High-Field Magnetic Resonance Imaging and High-Resolution Micro-Computed Tomography in Imaging the Mouse Inner Ear.The open neuroimaging journal · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe role of fibroblast growth factor and receptor (FGF/FGFR) signaling in bone development is well studied, partly because mutations in FGFRs cause human diseases of achondroplasia and FGFR-related craniosynostosis syndromes including Crouzon syndrome. The FGFR2c C342Y mutation is a frequent cause of Crouzon syndrome, characterized by premature cranial vault suture closure, midfacial deficiency, and neurocranial dysmorphology. Here, using newborn Fgfr2c(C342Y/+) Crouzon syndrome mice, we tested whether the phenotypic effects of this mutation go beyond the skeletal tissues of the skull, altering the development of other non-skeletal head tissues including the brain, the eyes, the nasopharynx, and the inner ears.
resultsQuantitative analysis of 3D multimodal imaging (high-resolution micro-computed tomography and magnetic resonance microscopy) revealed local differences in skull morphology and coronal suture patency between Fgfr2c(C342Y/+) mice and unaffected littermates, as well as changes in brain shape but not brain size, significant reductions in nasopharyngeal and eye volumes, and no difference in inner ear volume in Fgfr2c(C342Y/+) mice.
conclusionsThese findings provide an expanded catalogue of clinical phenotypes in Crouzon syndrome caused by aberrant FGF/FGFR signaling and evidence of the broad role for FGF/FGFR signaling in development and evolution of the vertebrate head.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.