ReviewNeuro-oncology2013
Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis.
Review in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- Giant cystic choroid plexus papilloma mimicking intracerebral hydatid cyst.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Article
- Cadherin 1 germline mutation co-occurs with medullary thyroid cancer and choroid plexus papilloma: A case report and review of literature.Surgical neurology international · 2025Article
- Diagnosis of choroid plexus papilloma: Current perspectives and future directions.Cancer pathogenesis and therapy · 2024Review
- Imaging of supratentorial intraventricular masses in children:a pictorial review- part 1.Neuroradiology · 2024Review
- A rare trifocal presentation of a choroid plexus papilloma: Case report and review of the literature.Brain & spine · 2024Review
- Atypical choroid plexus papilloma: Diagnosis and differentials: A case report.SAGE open medical case reports · 2024Article
- Article
- Posterior fossa choroidplexus papilloma in the pediatric population: case series and literature review.Arquivos de neuro-psiquiatria · 2023Review
- Shunt dependency in supratentorial intraventricular tumors depends on the extent of tumor resection.Acta neurochirurgica · 2023Article
- The choroid plexus: a missing link in our understanding of brain development and function.Physiological reviews · 2023Review
- In Vitro Models of the Blood-Cerebrospinal Fluid Barrier and Their Applications in the Development and Research of (Neuro)Pharmaceuticals.Pharmaceutics · 2022Review
- Experimental approaches for manipulating choroid plexus epithelial cells.Fluids and barriers of the CNS · 2022Review
- Article
- Molecular insights into malignant progression of atypical choroid plexus papilloma.Cold Spring Harbor molecular case studies · 2021Article
- Persistence of communicating hydrocephalus post choroid plexus tumor resection: Case reports and review of literature.Surgical neurology international · 2021Article
- Intracranial calcifications in childhood: Part 2.Pediatric radiology · 2020Review
- Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors.Histology and histopathology · 2020Article
- Emergence and Developmental Roles of the Cerebrospinal Fluid System.Developmental cell · 2020Review
- Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton.Oncology letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Choroid plexus papillomas are rare, benign tumors originating from the choroid plexus. Although generally found within the ventricular system, they can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. We sought to review recent advances in our understanding of the molecular biology and oncogenic pathways associated with this disease. A comprehensive PubMed literature review was conducted to identify manuscripts discussing the clinical, molecular, and genetic features of choroid plexus papillomas. Articles concerning diagnosis, treatment, and long-term patient outcomes were also reviewed. The introduction of atypical choroid plexus papilloma as a distinct entity has increased the need for accurate histopathologic diagnosis. Advances in immunohistochemical staining have improved our ability to differentiate choroid plexus papillomas from other intracranial tumors or metastatic lesions using combinations of key markers and mitotic indices. Recent findings have implicated Notch3 signaling, the transcription factor TWIST1, platelet-derived growth factor receptor, and the tumor necrosis factor-related apoptosis-inducing ligand pathway in choroid plexus papilloma tumorigenesis. A combination of commonly occurring chromosomal duplications and deletions has also been identified. Surgical resection remains the standard of care, although chemotherapy and radiotherapy may be considered for recurrent or metastatic lesions. While generally considered benign, these tumors possess a complex biology that sheds insight into other choroid plexus tumors, particularly malignant choroid plexus carcinomas. Improving our understanding of the molecular biology, genetics, and oncogenic pathways associated with this tumor will allow for the development of targeted therapies and improved outcomes for patients with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.