Evidence map›Paper›PMID 23172342›Full record

ArticleSexually transmitted infections2012

National HIV prevalence estimates for sub-Saharan Africa: controlling selection bias with Heckman-type selection models.

Daniel R Hogan, Joshua A Salomon, David Canning, James K Hammitt, Alan M Zaslavsky, Till Bärnighausen

Abstract read
In one paragraph

Article in Sexually transmitted infections, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

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23citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Are all biases missing data problems?Current epidemiology reports · 2015
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Daniel R HoganHarvard School of Public Health, Department of Global Health and Population, 665 Huntington Ave, Building 1, Boston, MA 02115, USA. dhogan@hsph.harvard.edu
Joshua A Salomon
David Canning
James K Hammitt
Alan M Zaslavsky
Till Bärnighausen

Funding

PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
The Center for the Global Demography of AgingP30AG024409 · NIA · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI BLOOM, DAVID E · 2004 to 2019
$7.9M
Impact of Antiretroviral Therapy on HIV Epidemic DynamicsR01MH083539 · NIMH · BROWN UNIVERSITY · PI LURIE, MARK NATHAN · 2009 to 2012
$2.2M
Understanding causal pathways of HIV acquisition and transmission: a multi-level,R01HD058482 · NICHD · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2008 to 2012
$1.2M
NIAID NIH HHS T32 AI007433NIAID NIH HHS T32-AI 007433NIA NIH HHS 5P30AG024409NIA NIH HHS P30 AG024409NICHD NIH HHS 1R01-HD058482-01NICHD NIH HHS R01 HD058482NIMH NIH HHS 1R01-MH083539-01NIMH NIH HHS R01 MH083539Wellcome Trust 097410
6 · The paper itself

Abstract

objectivesPopulation-based HIV testing surveys have become central to deriving estimates of national HIV prevalence in sub-Saharan Africa. However, limited participation in these surveys can lead to selection bias. We control for selection bias in national HIV prevalence estimates using a novel approach, which unlike conventional imputation can account for selection on unobserved factors.

methodsFor 12 Demographic and Health Surveys conducted from 2001 to 2009 (N=138 300), we predict HIV status among those missing a valid HIV test with Heckman-type selection models, which allow for correlation between infection status and participation in survey HIV testing. We compare these estimates with conventional ones and introduce a simulation procedure that incorporates regression model parameter uncertainty into confidence intervals.

resultsSelection model point estimates of national HIV prevalence were greater than unadjusted estimates for 10 of 12 surveys for men and 11 of 12 surveys for women, and were also greater than the majority of estimates obtained from conventional imputation, with significantly higher HIV prevalence estimates for men in Cote d'Ivoire 2005, Mali 2006 and Zambia 2007. Accounting for selective non-participation yielded 95% confidence intervals around HIV prevalence estimates that are wider than those obtained with conventional imputation by an average factor of 4.5.

conclusionsOur analysis indicates that national HIV prevalence estimates for many countries in sub-Saharan African are more uncertain than previously thought, and may be underestimated in several cases, underscoring the need for increasing participation in HIV surveys. Heckman-type selection models should be included in the set of tools used for routine estimation of HIV prevalence.

Indexed as

Epidemiologic MethodsSelection BiasAdolescentAdultAfrica South of the SaharaFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceYoung Adult

Identifiers

PMID23172342
PMCPMC3512441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.