ArticleNucleic acids research2013
Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- RNA Pol II-dependent transcription efficiency fine-tunes A-to-I editing levels.Genome research · 2024Article
- A new strategy to increase RNA editing at the Q/R site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2.Journal of neuroscience methods · 2021Article
- Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.Cellular and molecular life sciences : CMLS · 2021Article
- To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis.Critical reviews in biochemistry and molecular biology · 2021Review
- Circadian Regulation of GluA2 mRNA Processing in the Rat Suprachiasmatic Nucleus and Other Brain Structures.Molecular neurobiology · 2021Article
- Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b.The Journal of biological chemistry · 2020Article
- ADAR-deficiency perturbs the global splicing landscape in mouse tissues.Genome research · 2020Article
- Article
- A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing.Genome research · 2019Article
- ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity.Journal of cell science · 2018Article
- RNA editing in nascent RNA affects pre-mRNA splicing.Genome research · 2018Article
- The Role of RNA Editing in Cancer Development and Metabolic Disorders.Frontiers in endocrinology · 2018Review
- The Good and the Bad of Glutamate Receptor RNA Editing.Molecular neurobiology · 2017Review
- Review
- Adenosine to Inosine editing frequency controlled by splicing efficiency.Nucleic acids research · 2016Article
- Review
- Functional Impact of RNA editing and ADARs on regulation of gene expression: perspectives from deep sequencing studies.Cell & bioscience · 2014Review
- Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides.ACS chemical biology · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein function. Functional consequences are only known for some editing sites and the combinatorial effect between multiple sites (functional epistasis) is currently unclear. Similarly, the interplay between RNA editing and splicing, which impacts on post-transcriptional gene regulation, has not been resolved. Here, we describe a versatile antisense approach, which will aid resolving these open questions. We have developed and characterized morpholino oligos targeting the most efficiently edited site--the AMPA receptor GluA2 Q/R site. We show that inhibition of editing closely correlates with intronic editing efficiency, which is linked to splicing efficiency. In addition to providing a versatile tool our data underscore the unique efficiency of a physiologically pivotal editing site.
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