Evidence map›Paper›PMID 23172234›Full record

ReviewInternational archives of allergy and immunology2013

Strategies to query and display allergy-derived epitope data from the immune epitope database.

Kerrie Vaughan, Bjoern Peters, Mark Larche, Anna Pomes, David Broide, Alessandro Sette

Abstract readReview
In one paragraph

Review in International archives of allergy and immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Prediction and identification of epitopes in the Echinococcus multilocularis thrombospondin 3 antigen.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Bioinformatic prediction of epitopes in the Emy162 antigen ofExperimental and therapeutic medicine · 2013
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerrie VaughanImmune Epitope Database and Analysis Resource (IEDB), La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. kvaughan@liai.org
Bjoern Peters
Mark Larche
Anna Pomes
David Broide
Alessandro Sette

Funding

Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
Understanding mechanisms in specific immunotherapy (SIT)U19AI100275 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SETTE, ALESSANDRO · 2012 to 2017
$8.1M
HHS HH-SN26620040006CNIAID NIH HHS 1U19AI100275-01NIAID NIH HHS HHSH266200400006CNIAID NIH HHS HHSN272200700048CNIAID NIH HHS R01 AI077653NIAID NIH HHS R01AI77653-1A2S1NIAID NIH HHS U19 AI100275
6 · The paper itself

Abstract

The recognition of specific epitopes on allergens by antibodies and T cells is a key element in allergic processes. Analysis of epitope data may be of interest for basic immunopathology or for potential application in diagnostics or immunotherapy. The Immune Epitope Database (IEDB) is a freely available repository of epitope data from infectious disease agents, as well as epitopes defined for allergy, autoimmunity, and transplantation. The IEDB curates the experiments associated with each epitope and thus provides a variety of different ways to search the data. This review aims to demonstrate the utility of the IEDB and its query strategies, including searching by epitope structure (peptidic/nonpeptidic), by assay methodology, by host, by the allergen itself, or by the organism from which the allergen was derived. Links to tools for visualization of 3-D structures, epitope prediction, and analyses of B and T cell reactivity by host response frequency score are also highlighted.

Indexed as

Databases, FactualDatabases, ProteinAllergensAnimalsCrystallography, X-RayData DisplayDesensitization, ImmunologicEpitopesEpitopes, T-LymphocyteHumansHypersensitivityLymphocyte ActivationPeptidesProteinsT-LymphocytesAllergensEpitopesEpitopes, T-LymphocytePeptidesProteins

Identifiers

PMID23172234
PMCPMC3629817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.