ArticleLab on a chip2013
Digitally programmable microfluidic automaton for multiscale combinatorial mixing and sample processing.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Biomarkers on the Icy Jovian Moons: Can Europa Also Provide Insights into Life's Origin?Life (Basel, Switzerland) · 2026Review
- Controlling Biomedical Devices Using Pneumatic Logic.Annals of biomedical engineering · 2025Article
- Early Technology Readiness Level (TRL) Development of the Microfluidic Inorganic Conductivity Detector for Europa and the Solenoid-Based Actuator Assembly for Impact Penetrators.Sensors (Basel, Switzerland) · 2024Article
- A programmable microfluidic platform to monitor calcium dynamics in microglia during inflammation.Microsystems & nanoengineering · 2024Article
- Operation of a programmable microfluidic organic analyzer under microgravity conditions simulating space flight environments.NPJ microgravity · 2023Article
- The Use of Sensors in Blood-Brain Barrier-on-a-Chip Devices: Current Practice and Future Directions.Biosensors · 2023Review
- Programmable Droplet Microfluidics Based on Machine Learning and Acoustic Manipulation.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Article
- Microvalve array fabrication using selective PDMS (polydimethylsiloxane) bonding through Perfluorooctyl-trichlorosilane passivation for long-term space exploration.Scientific reports · 2022Article
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- Article
- Thermally-actuated microfluidic membrane valve for point-of-care applications.Microsystems & nanoengineering · 2021Article
- Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids.Nature communications · 2020Article
- Experimental fluid dynamics characterization of a novel micropump-mixer.Biomicrofluidics · 2020Article
- Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis.World journal of stem cells · 2019Review
- A novel wide-range microfluidic dilution device for drug screening.Biomicrofluidics · 2019Article
- Single-Layered Microfluidic Network-Based Combinatorial Dilution for Standard Simplex Lattice Design.Micromachines · 2018Article
- Normally closed plunger-membrane microvalve self-actuated electrically using a shape memory alloy wire.Microfluidics and nanofluidics · 2018Article
- End-to-end automated microfluidic platform for synthetic biology: from design to functional analysis.Journal of biological engineering · 2016Article
- Towards combinatorial mixing devices without any pumps by open-capillary channels: fundamentals and applications.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A digitally programmable microfluidic Automaton consisting of a 2-dimensional array of pneumatically actuated microvalves is programmed to perform new multiscale mixing and sample processing operations. Large (μL-scale) volume processing operations are enabled by precise metering of multiple reagents within individual nL-scale valves followed by serial repetitive transfer to programmed locations in the array. A novel process exploiting new combining valve concepts is developed for continuous rapid and complete mixing of reagents in less than 800 ms. Mixing, transfer, storage, and rinsing operations are implemented combinatorially to achieve complex assay automation protocols. The practical utility of this technology is demonstrated by performing automated serial dilution for quantitative analysis as well as the first demonstration of on-chip fluorescent derivatization of biomarker targets (carboxylic acids) for microchip capillary electrophoresis on the Mars Organic Analyzer. A language is developed to describe how unit operations are combined to form a microfluidic program. Finally, this technology is used to develop a novel microfluidic 6-sample processor for combinatorial mixing of large sets (>2(6) unique combinations) of reagents. The digitally programmable microfluidic Automaton is a versatile programmable sample processor for a wide range of process volumes, for multiple samples, and for different types of analyses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.