ArticleAmerican journal of epidemiology2013
Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 183 citations in OpenAlex.
- Cancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH).Environment international · 2021Pooled it
- Cancer and occupational exposure to pesticides: an umbrella review.International archives of occupational and environmental health · 2021Pooled it
- Prostate Cancer and Asbestos: A Systematic Review and Meta-Analysis.The Permanente journal · 2020Pooled it
- Endocrine-Disrupting Pesticides as Drivers of Human Disease: Mechanistic Toxicology and Life-Course Health Effects.International journal of molecular sciences · 2026Review
- Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations.Environmental health perspectives · 2026Article
- Research Trends on Pesticide Exposure and Cancer Development: A Global Literature Review (2005-2024).International journal of environmental research and public health · 2026Review
- Drinking water nitrate, disinfection byproducts, and prostate cancer incidence in the Agricultural Health Study.Journal of the National Cancer Institute · 2026Article
- Article
- Persistent organic pollutants and prostate cancer: multiple mechanisms and comprehensive control strategies.Frontiers in cell and developmental biology · 2026Review
- Article
- Organochlorine pesticide use and mosaic loss of chromosome Y in a study of male farmers.Environmental research · 2025Article
- Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis.International journal of hygiene and environmental health · 2025Article
- Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska.Cancer medicine · 2025Article
- Review of the effect of atrazine on the HPG axes and steroidogenic pathways in males: relevance for testicular and prostate cancer.Frontiers in toxicology · 2025Review
- Impact of Endocrine Disruptors on the Genitourinary Tract.Journal of xenobiotics · 2024Review
- Examining the Completeness of Industry and Occupation Data Among Patients Newly Diagnosed with Cancer in North Carolina.North Carolina medical journal · 2024Article
- An exploratory analysis of the impact of area-level exposome on geographic disparities in aggressive prostate cancer.Scientific reports · 2024Article
- An Updated Evaluation of Atrazine-Cancer Incidence Associations among Pesticide Applicators in the Agricultural Health Study Cohort.Environmental health perspectives · 2024Article
- A latent functional approach for modeling the effects of multidimensional exposures on disease risk.Statistics in medicine · 2023Article
- Joint associations between established genetic susceptibility loci, pesticide exposures, and risk of prostate cancer.Environmental research · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Because pesticides may operate through different mechanisms, the authors studied the risk of prostate cancer associated with specific pesticides in the Agricultural Health Study (1993-2007). With 1,962 incident cases, including 919 aggressive prostate cancers among 54,412 applicators, this is the largest study to date. Rate ratios and 95% confidence intervals were calculated by using Poisson regression to evaluate lifetime use of 48 pesticides and prostate cancer incidence. Three organophosphate insecticides were significantly associated with aggressive prostate cancer: fonofos (rate ratio (RR) for the highest quartile of exposure (Q4) vs. nonexposed = 1.63, 95% confidence interval (CI): 1.22, 2.17; P(trend) < 0.001); malathion (RR for Q4 vs. nonexposed = 1.43, 95% CI: 1.08, 1.88; P(trend) = 0.04); and terbufos (RR for Q4 vs. nonexposed = 1.29, 95% CI: 1.02, 1.64; P(trend) = 0.03). The organochlorine insecticide aldrin was also associated with increased risk of aggressive prostate cancer (RR for Q4 vs. nonexposed = 1.49, 95% CI: 1.03, 2.18; P(trend) = 0.02). This analysis has overcome several limitations of previous studies with the inclusion of a large number of cases with relevant exposure and detailed information on use of specific pesticides at 2 points in time. Furthermore, this is the first time specific pesticides are implicated as risk factors for aggressive prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.