Evidence map›Paper›PMID 23171880›Full record

Trial reportAmerican journal of epidemiology2013

Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study.

Mathilde Touvier, Léopold Fezeu, Namanjeet Ahluwalia, Chantal Julia, Nathalie Charnaux, Angela Sutton, Caroline Méjean, Paule Latino-Martel, Serge Hercberg, Pilar Galan and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 16 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 16 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  13. Plasma C-reactive protein and risk of breast cancer in two prospective studies and a meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mathilde TouvierNutritional Epidemiology Unit, INSERM U557, Paris 13 University, 74 rue Marcel Cachin, F-93017 Bobigny, France. m.touvier@uren.smbh.univ-paris13.fr
Léopold Fezeu
Namanjeet Ahluwalia
Chantal Julia
Nathalie Charnaux
Angela Sutton
Caroline Méjean
Paule Latino-Martel
Serge Hercberg
Pilar Galan
Sébastien Czernichow
Equipe de Recherche en Epidémiologie Nutritionnelle · FRInserm · FRUniversité Sorbonne Paris Nord · FRNord University · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors' objective was to prospectively examine the relations between these biomarkers and cancer risk. A nested case-control study was designed within the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) Study, a nationwide French cohort study, to include all first primary incident cancers diagnosed between 1994 and 2007 (n = 512). Cases were matched with randomly selected controls (n = 1,024) on sex, age (in 2-year strata), body mass index (weight (kg)/height (m)(2); <25 vs. ≥25), and SU.VI.MAX intervention group. Conditional logistic regression was used to study the associations between prediagnostic levels of high-sensitivity C-reactive protein (hs-CRP), adiponectin, leptin, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble E-selectin, and monocyte chemoattractant protein 1 and cancer risk. All statistical tests were 2-sided. Plasma sICAM-1 level was positively associated with breast cancer risk (for quartile 4 vs. quartile 1, multivariate odds ratio (OR) = 1.86, 95% confidence interval (CI): 1.06, 3.26; P(trend) = 0.048). Plasma hs-CRP level was positively associated with prostate cancer risk (for quartile 4 vs. quartile 1, multivariate OR = 3.04, 95% CI: 1.28, 7.23; P(trend) = 0.03). These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated with increased prostate and breast cancer risk, respectively.

Indexed as

AdiponectinAdiposityAdultBiomarkersBody Mass IndexBreast NeoplasmsCase-Control StudiesCell Adhesion MoleculesChemokine CCL2C-Reactive ProteinDouble-Blind MethodEndotheliumFemaleHealth BehaviorHumansInflammationAdiponectinBiomarkersCell Adhesion MoleculesChemokine CCL2C-Reactive ProteinLeptin

Identifiers

PMID23171880
PMCPMC3529490
OpenAlexW2131665952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.