ArticleMolecular biology and evolution2013
Anisotropic isolation by distance: the main orientations of human genetic differentiation.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Biogeographic Perspectives on Human Genetic Diversification.Molecular biology and evolution · 2024Article
- Targeted sequencing of high-density SNPs provides an enhanced tool for forensic applications and genetic landscape exploration in Chinese Korean ethnic group.Human genomics · 2023Article
- Relevance ofPharmaceutics · 2022Article
- Species delimitation and mitonuclear discordance within a species complex of biting midges.Scientific reports · 2022Article
- High dispersal capacity of Culicoides obsoletus (Diptera: Ceratopogonidae), vector of bluetongue and Schmallenberg viruses, revealed by landscape genetic analyses.Parasites & vectors · 2021Article
- Next generation sequencing of a set of ancestry-informative SNPs: ancestry assignment of three continental populations and estimating ancestry composition for Mongolians.Molecular genetics and genomics : MGG · 2020Article
- Space is the Place: Effects of Continuous Spatial Structure on Analysis of Population Genetic Data.Genetics · 2020Article
- Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations.Genome biology · 2019Article
- Isotropic and anisotropic processes influence fine-scale spatial genetic structure of a keystone tropical plant.AoB PLANTS · 2018Article
- Novel probabilistic models of spatial genetic ancestry with applications to stratification correction in genome-wide association studies.Bioinformatics (Oxford, England) · 2017Article
- Inferring Recent Demography from Isolation by Distance of Long Shared Sequence Blocks.Genetics · 2017Article
- Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset.Scientific reports · 2017Article
- Recent advances in the study of fine-scale population structure in humans.Current opinion in genetics & development · 2016Review
- Detecting Genomic Signatures of Natural Selection with Principal Component Analysis: Application to the 1000 Genomes Data.Molecular biology and evolution · 2016Article
- Isolation-by-distance-and-time in a stepping-stone model.Theoretical population biology · 2016Article
- The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach.Scientifica · 2016Review
- Fine-scale human genetic structure in Western France.European journal of human genetics : EJHG · 2015Article
- Detecting individual ancestry in the human genome.Investigative genetics · 2015Article
- Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe.PLoS genetics · 2014Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic differentiation among human populations is greatly influenced by geography due to the accumulation of local allele frequency differences. However, little is known about the possibly different increment of genetic differentiation along the different geographical axes (north-south, east-west, etc.). Here, we provide new methods to examine the asymmetrical patterns of genetic differentiation. We analyzed genome-wide polymorphism data from populations in Africa (n = 29), Asia (n = 26), America (n = 9), and Europe (n = 38), and we found that the major orientations of genetic differentiation are north-south in Europe and Africa, and east-west in Asia, but no preferential orientation was found in the Americas. Additionally, we showed that the localization of the individual geographic origins based on single nucleotide polymorphism data was not equally precise along all orientations. Confirming our findings, we obtained that, in each continent, the orientation along which the precision is maximal corresponds to the orientation of maximum differentiation. Our results have implications for interpreting human genetic variation in terms of isolation by distance and spatial range expansion processes. In Europe, for instance, the precise northnorthwest-southsoutheast axis of main European differentiation cannot be explained by a simple Neolithic demic diffusion model without admixture with the local populations because in that case the orientation of greatest differentiation should be perpendicular to the direction of expansion. In addition to humans, anisotropic analyses can guide the description of genetic differentiation for other organisms and provide information on expansions of invasive species or the processes of plant dispersal.
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