ArticleMolecular biology and evolution2013
Human microRNAs originated from two periods at accelerated rates in mammalian evolution.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
- MicroRNAs are deeply linked to the emergence of the complex octopus brain.Science advances · 2022Article
- Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risks.Human genetics · 2022Article
- A comparative analysis of heart microRNAs in vertebrates brings novel insights into the evolution of genetic regulatory networks.BMC genomics · 2021Article
- Analysis of conserved miRNAs in cynomolgus macaque genome using small RNA sequencing and homology searching.PeerJ · 2020Article
- Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles.BMC genomics · 2019Article
- miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse.Matrix biology : journal of the International Society for Matrix Biology · 2019Article
- Well-Annotated microRNAomes Do Not Evidence Pervasive miRNA Loss.Genome biology and evolution · 2018Article
- Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution.PloS one · 2018Article
- Primate-specific Long Non-coding RNAs and MicroRNAs.Genomics, proteomics & bioinformatics · 2017Review
- Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs.Frontiers in genetics · 2017Review
- The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity.BMC genomics · 2016Article
- Differences in molecular evolutionary rates among microRNAs in the human and chimpanzee genomes.BMC genomics · 2016Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- Evolutionary Transitions of MicroRNA-Target Pairs.Genome biology and evolution · 2016Article
- Host gene constraints and genomic context impact the expression and evolution of human microRNAs.Nature communications · 2016Article
- ncRNA orthologies in the vertebrate lineage.Database : the journal of biological databases and curation · 2016Article
- Article
- A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome.Annual review of genetics · 2015Review
- Microevolution of nematode miRNAs reveals diverse modes of selection.Genome biology and evolution · 2014Article
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5 authors.
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Abstract
MicroRNAs (miRNAs) are short, noncoding RNAs that modulate genes posttranscriptionally. Frequent gains and losses of miRNA genes have been reported to occur during evolution. However, little is known systematically about the periods of evolutionary origin of the present miRNA gene repertoire of an extant mammalian species. Thus, in this study, we estimated the evolutionary periods during which each of 1,433 present human miRNA genes originated within 15 periods, from human to platypus-human common ancestral branch and a class "conserved beyond theria," primarily using multiple genome alignments of 38 species, plus the pairwise genome alignments of five species. The results showed two peak periods in which the human miRNA genes originated at significantly accelerated rates. The most accelerated rate appeared in the period of the initial phase of hominoid lineage, and the second appeared shortly before Laurasiatherian divergence. Approximately 53% of the present human miRNA genes have originated within the simian lineage to human. In particular, approximately 28% originated within the hominoid lineage. The early phase of placental mammal radiation comprises approximately 28%, while no more than 15% of human miRNAs have been conserved beyond placental mammals. We also clearly showed a general trend, in which the miRNA expression level decreases as the miRNA becomes younger. Intriguingly, amid this decreasing trend of expression, we found one significant rise in the expression level that corresponded to the initial phase of the hominoid lineage, suggesting that increased functional acquisitions of miRNAs originated at this particular period.
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