Evidence map›Paper›PMID 23171733›Full record

ArticleCritical care (London, England)2012

CXCR3 blockade: a novel anti-sepsis approach?

Matthew J Delano, Lyle L Moldawer

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew J Delano
Lyle L Moldawer
University of Florida · US

Funding

Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
REGULATION ON MONOKINE PRODUCTION IN TRAUMA AND SURGERYR01GM040586 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MOLDAWER, LYLE L · 1988 to 2016
$2.6M
Novel Mechanisms and Approaches to Treat Neonatal SepsisR01GM097531 · NIGMS · UNIVERSITY OF FLORIDA · PI LARSON, SHAWN DAVID, MOLDAWER, LYLE L · 2011 to 2018
$2.3M
Myeloid Suppressor Cells in Sepsis and TraumaR01GM081923 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2008 to 2014
$1.8M
NIGMS NIH HHS R01 GM040586NIGMS NIH HHS R01 GM081923NIGMS NIH HHS R01 GM097531NIGMS NIH HHS T32 GM008721NIGMS NIH HHS T32 GM-08431
6 · The paper itself

Abstract

Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed.

Indexed as

Disease Models, AnimalImmunoglobulin GAnimalsAntibodies, Anti-IdiotypicReceptors, CXCR3SepsisAntibodies, Anti-IdiotypicImmunoglobulin GReceptors, CXCR3

Identifiers

PMID23171733
PMCPMC3672571
OpenAlexW1968975702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.