ArticleEnvironmental health perspectives2013
In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026Observational
- Association of prenatal chlorpyrifos exposure with sexually dimorphic differences in anogenital distance among Thai farmworker children.Environmental research · 2024Article
- Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort.Toxics · 2022Article
- Effects of endocrine disruptors on fetal testis development, male puberty, and transition age.Endocrine · 2021Review
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Associations between endocrine disrupting chemicals and equine metabolic syndrome phenotypes.Chemosphere · 2019Article
- Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.EFSA journal. European Food Safety Authority · 2018Article
- A sensitive, rapid, and simple DR-EcoScreen bioassay for the determination of PCDD/Fs and dioxin-like PCBs in environmental and food samples.Environmental science and pollution research international · 2018Article
- WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding.Archives of toxicology · 2017Review
- Article
- Anogenital distance as a marker of androgen exposure in humans.Andrology · 2016Review
- Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences.Human reproduction (Oxford, England) · 2016Article
- Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta.Environment international · 2014Article
- Concurrent fetal exposure to multiple environmental chemicals along the U.S.-Mexico border: an exploratory study in Brownsville, Texas.International journal of environmental research and public health · 2014Article
- Anogenital distance and its application in environmental health research.Environmental science and pollution research international · 2014Review
- Behavioral sexual dimorphism in school-age children and early developmental exposure to dioxins and PCBs: a follow-up study of the Duisburg Cohort.Environmental health perspectives · 2014Article
- Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data.Environmental health perspectives · 2014Article
- Prenatal exposure to stressful life events is associated with masculinized anogenital distance (AGD) in female infants.Physiology & behavior · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnogenital distance in animals is used as a measure of fetal androgen action. Prenatal exposure to dioxins and dioxin-like compounds in rodents causes reproductive changes in male offspring and decreases anogenital distance.
objectiveWe assessed whether in utero exposure to dioxins and dioxin-like compounds adversely influences anogenital distance in newborns and young children (median age, 16 months; range, 1-31 months).
methodsWe measured anogenital distance among participants of the "Rhea" mother-child cohort study in Crete and the Hospital del Mar (HMAR) cohort in Barcelona. Anogenital distance (AGD; anus to upper penis), anoscrotal distance (ASD; anus to scrotum), and penis width (PW) were measured in 119 newborn and 239 young boys; anoclitoral (ACD; anus to clitoris) and anofourchetal distance (AFD; anus to fourchette) were measured in 118 newborn and 223 young girls. We estimated plasma dioxin-like activity in maternal blood samples collected at delivery with the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX®) bioassay.
resultsAnogenital distances were sexually dimorphic, being longer in males than females. Plasma dioxin-like activity was negatively associated with AGD in male newborns. The estimated change in AGD per 10 pg CALUX®-toxic equivalent/g lipid increase was -0.44 mm (95% CI: -0.80, -0.08) after adjusting for confounders. Negative but smaller and nonsignificant associations were observed for AGD in young boys. No associations were found in girls.
conclusionsMale infants may be susceptible to endocrine-disrupting effects of dioxins. Our findings are consistent with the experimental animal evidence used by the Food and Agriculture Organization/World Health Organization to set recommendations for human dioxin intake.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.