ArticleSocial cognitive and affective neuroscience2014
Aberrant neurocognitive processing of fear in young girls with Turner syndrome.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Reduced effects of social feedback on learning in Turner syndrome.Scientific reports · 2023Article
- Longitudinal investigation of cognition, social competence, and anxiety in children and adolescents with Turner syndrome.Hormones and behavior · 2023Article
- Empathic Accuracy in Adolescent Girls with Turner Syndrome.Journal of autism and developmental disorders · 2022Article
- Altered Brain Structure in Infants with Turner Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Clinical developmental, neuropsychological, and social-emotional features of Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Overview of Social Cognitive Dysfunctions in Rare Developmental Syndromes With Psychiatric Phenotype.Frontiers in pediatrics · 2018Review
- Normal Performance in Non-Visual Social Cognition Tasks in Women with Turner Syndrome.Frontiers in endocrinology · 2018Article
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Morphological Changes of Amygdala in Turner Syndrome Patients.CNS neuroscience & therapeutics · 2016Article
- Sex differences and stress across the lifespan.Nature neuroscience · 2015Review
- Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males.PloS one · 2015Article
- Cognition and behavior in Turner syndrome: a brief review.Pediatric endocrinology reviews : PER · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Appraisal of fearful stimuli is an integral aspect of social cognition. Neural circuitry underlying this phenomenon has been well-described and encompasses a distributed network of affective and cognitive nodes. Interestingly, this ability to process fearful faces is impaired in Turner syndrome (TS), a genetic disorder of females in which all or part of an X chromosome is missing. However, neurofunctional correlates for this impairment have not been well-studied, particularly in young girls. Given that the core features of TS include X chromosome gene haploinsufficiency and secondary sex hormone deficiencies, investigation of fearful face processing may provide insights into the influence of X chromosome gene expression on this network. Therefore, we examined behavioral and neural responses during an explicit emotional face labeling task in 14 prepubertal girls with TS and 16 typically developing age-matched controls (6-13 years). We demonstrate that girls with TS have a specific impairment in the identification of fearful faces and show decreased activation in several cognitive control regions, including the anterior dorsal anterior cingulate cortex, dorsolateral prefrontal cortex and posterior cingulate gyrus. Our results indicate that aberrant functional activation in dorsal cognitive regions plays an integral role in appraisal of, and regulation of response to fear in TS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.