ArticleMolecular biology of the cell2013
TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells.Microbial ecology · 2026Review
- The phenomenon of anhydrobiosis-structural and functional changes in yeast cells.Applied microbiology and biotechnology · 2025Review
- How to Survive without Water: A Short Lesson on the Desiccation Tolerance of Budding Yeast.International journal of molecular sciences · 2024Review
- Physiological and genetic regulation of anhydrobiosis in yeast cells.Archives of microbiology · 2023Review
- Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.EMBO reports · 2023Article
- Changes in genotoxic stress response, ribogenesis and PAP (3'-phosphoadenosine 5'-phosphate) levels are associated with loss of desiccation tolerance in overprimed Medicago truncatula seeds.Plant, cell & environment · 2022Article
- Purine Auxotrophic Starvation Evokes Phenotype Similar to Stationary Phase Cells in Budding Yeast.Journal of fungi (Basel, Switzerland) · 2021Article
- Modeling in yeast how rDNA introns slow growth and increase desiccation tolerance in lichens.G3 (Bethesda, Md.) · 2021Article
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- The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata.BMC genomics · 2019Article
- Survival of Extremophilic Yeasts in the Stratospheric Environment during Balloon Flights and in Laboratory Simulations.Applied and environmental microbiology · 2018Article
- Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomidProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases.PLoS genetics · 2016Article
- Decoding the stem cell quiescence cycle--lessons from yeast for regenerative biology.Journal of cell science · 2015Review
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- Yeast Tolerance to Various Stresses Relies on the Trehalose-6P Synthase (Tps1) Protein, Not on Trehalose.The Journal of biological chemistry · 2015Article
- Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Acquisition and loss of desiccation tolerance in seeds: from experimental model to biological relevance.Planta · 2015Review
- Effect of nitrogen starvation on desiccation tolerance of Arctic Microcoleus strains (cyanobacteria).Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Tolerance to desiccation in cultures of Saccharomyces cerevisiae is inducible; only one in a million cells from an exponential culture survive desiccation compared with one in five cells in stationary phase. Here we exploit the desiccation sensitivity of exponentially dividing cells to understand the stresses imposed by desiccation and their stress response pathways. We found that induction of desiccation tolerance is cell autonomous and that there is an inverse correlation between desiccation tolerance and growth rate in glucose-, ammonia-, or phosphate-limited continuous cultures. A transient heat shock induces a 5000-fold increase in desiccation tolerance, whereas hyper-ionic, -reductive, -oxidative, or -osmotic stress induced much less. Furthermore, we provide evidence that the Sch9p-regulated branch of the TOR and Ras-cAMP pathway inhibits desiccation tolerance by inhibiting the stress response transcription factors Gis1p, Msn2p, and Msn4p and by activating Sfp1p, a ribosome biogenesis transcription factor. Among 41 mutants defective in ribosome biogenesis, a subset defective in 60S showed a dramatic increase in desiccation tolerance independent of growth rate. We suggest that reduction of a specific intermediate in 60S biogenesis, resulting from conditions such as heat shock and nutrient deprivation, increases desiccation tolerance.
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