ArticleBMC nephrology2012
Renal AA-amyloidosis in intravenous drug users--a role for HIV-infection?
Article in BMC nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Trends in diagnosis of amyloid kidney disease in people who inject drugs (PWID).Preventive medicine reports · 2026Article
- Different Sequential Renal Involvement in a Patient With HIV and Hepatitis C: From HIV- or Leishmaniasis-Related Collapsing Glomerulosclerosis to Direct-Acting Antivirals' Renal Amyloidosis.Case reports in infectious diseases · 2026Article
- Treatment of renal AA-Amyloidosis associated with human immunodeficiency virus infection: a case report.CEN case reports · 2021Article
- The role of cardiac imaging in the management of non-ischemic cardiovascular diseases in human immunodeficiency virus infection.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Pattern of renal amyloidosis in South Africa.BMC nephrology · 2019Article
- Key role of renal biopsy in management of progressive chronic kidney disease in liver graft recipients.Journal of nephrology · 2019Article
- Secondary amyloidosis associated with heroin use and recurrent infections - A case report.Annals of medicine and surgery (2012) · 2019Article
- 'Care and Prevent': rationale for investigating skin and soft tissue infections and AA amyloidosis among people who inject drugs in London.Harm reduction journal · 2018Observational
- Intravenous drug users who require dialysis: causes of renal failure and outcomes.Clinical kidney journal · 2018Article
- Multiple papular lesions in a patient with HIV and/or AIDS and coinfected with hepatitis B virus: Amyloidosis.Southern African journal of HIV medicine · 2017Article
- Nephrotoxicity of methadone: a systematic review.SpringerPlus · 2016Review
- Systemic AA amyloidosis: epidemiology, diagnosis, and management.Clinical epidemiology · 2014Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.
methodsRetrospective investigation including all patients with prior or present IVDU that underwent renal biopsy because of chronic kidney disease between 01.04.2002 and 31.03.2012 in the city of Frankfurt/Main, Germany.
resultsTwenty four patients with IVDU underwent renal biopsy because of progressive chronic kidney disease or proteinuria. Renal AA-amyloidosis was the predominant cause of renal failure in 50% of patients. Membranoproliferative glomerulonephritis (GN) was the second most common cause found in 21%. Patients with AA-amyloidosis were more likely to be HIV infected (67 vs.17%; p=0.036) and tended to have a higher rate of repeated systemic infections (92 vs. 50%; p=0.069). Patients with AA-amyloidosis presented with progressive renal disease and nephrotic-range proteinuria but most patients had no peripheral edema or systemic hypertension. Development of proteinuria preceded the decline of GFR for approximately 1-2 years.
conclusionsAA-amyloidosis was the predominant cause of progressive renal disease in the last 10 years in patients with IVDU. The highest rate of AA-amyloidosis observed was seen in HIV infected patients with IVDU. We speculate that chronic HIV-infection as well as the associated immunosuppression might promote development of AA-amyloidosis by increasing frequency and duration of infections acquired by IVDU.
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