ArticleMicrobiologyOpen2012
Evidence for the involvement of the anthranilate degradation pathway in Pseudomonas aeruginosa biofilm formation.
Article in MicrobiologyOpen, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
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- Biofilm matrix: a multifaceted layer of biomolecules and a defensive barrier against antimicrobials.Archives of microbiology · 2024Review
- RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms.Nature communications · 2023Article
- Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects.Molecules (Basel, Switzerland) · 2022Review
- Anthranilate Acts as a Signal to Modulate Biofilm Formation, Virulence, and Antibiotic Tolerance of Pseudomonas aeruginosa and Surrounding Bacteria.Microbiology spectrum · 2022Article
- Comparative Investigation of 15 Xenobiotic-MetabolizingApplied and environmental microbiology · 2021Article
- Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Delineation of a Subgroup of the Genus Paraburkholderia, Including P. terrae DSM 17804T, P. hospita DSM 17164T, and Four Soil-Isolated Fungiphiles, Reveals Remarkable Genomic and Ecological Features-Proposal for the Definition of a P. hospita Species Cluster.Genome biology and evolution · 2020Article
- Toward Biorecycling: Isolation of a Soil Bacterium That Grows on a Polyurethane Oligomer and Monomer.Frontiers in microbiology · 2020Article
- The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis.Hepatology (Baltimore, Md.) · 2018Article
- Antibiofilm agents: A new perspective for antimicrobial strategy.Journal of microbiology (Seoul, Korea) · 2017Review
- A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells.Oncotarget · 2017Article
- Anti-biofilm effects of anthranilate on a broad range of bacteria.Scientific reports · 2017Article
- Biofilm dispersion in Pseudomonas aeruginosa.Journal of microbiology (Seoul, Korea) · 2016Review
- Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism.PLoS computational biology · 2015Article
- Anthranilate deteriorates the structure of Pseudomonas aeruginosa biofilms and antagonizes the biofilm-enhancing indole effect.Applied and environmental microbiology · 2015Article
- Bacterial degradation of monocyclic aromatic amines.Frontiers in microbiology · 2015Review
- Predicting Ecological Roles in the Rhizosphere Using Metabolome and Transportome Modeling.PloS one · 2015Article
- Catechol biosynthesis from glucose in Escherichia coli anthranilate-overproducer strains by heterologous expression of anthranilate 1,2-dioxygenase from Pseudomonas aeruginosa PAO1.Microbial cell factories · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial biofilms are complex cell communities found attached to surfaces and surrounded by an extracellular matrix composed of exopolysaccharides, DNA, and proteins. We investigated the whole-genome expression profile of Pseudomonas aeruginosa sessile cells (SCs) present in biofilms developed on a glass wool substratum. The transcriptome and proteome of SCs were compared with those of planktonic cell cultures. Principal component analysis revealed a biofilm-specific gene expression profile. Our study highlighted the overexpression of genes controlling the anthranilate degradation pathway in the SCs grown on glass wool for 24 h. In this condition, the metabolic pathway that uses anthranilate for Pseudomonas quinolone signal production was not activated, which suggested that anthranilate was primarily being consumed for energy metabolism. Transposon mutants defective for anthranilate degradation were analyzed in a simple assay of biofilm formation. The phenotypic analyses confirmed that P. aeruginosa biofilm formation partially depended on the activity of the anthranilate degradation pathway. This work points to a new feature concerning anthranilate metabolism in P. aeruginosa SCs.
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Registered trials
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